Protein Alignment TESK1 and lrk-1

DIOPT Version :10

• Sequence 1: NP_006276.2
• Gene: TESK1 / 7016
• HGNCID: 11731
• Length: 626
• Species: Homo sapiens
• Sequence 2: NP_492839.4
• Gene: lrk-1 / 172995
• WormBaseID: WBGene00003068
• Length: 2393
• Species: Caenorhabditis elegans
• Alignment Length: 348
• Identity: 96/348 - (27%)
• Similarity: 137/348 - (39%)
• Gaps: 105/348 - (30%)

Human    24 PGPGGTGGGPGRGRPSSYRALRSAVSSLARVD-DFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKM 87
            ||||        ||||:..|.::|.....|.. :|.|....
 Worm  1733 PGPG--------GRPSALAAYKAAADKWKRDSMEFACRAYC------------------------ 1765

Human    88 NKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPE----PLS 148
                    .:.:|:.|::|::|||::..:|||..  .|..:.|....|.|.|||.|..    .||
 Worm  1766 --------TSRQELSLLSRMKHPNVIGLVGVCTF--PLSLVVELAPLGALNQLLGSHRKAGTKLS 1820

Human   149 WPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFT------AVVGDFGLAEKIPVYR 207
            ..|....|:.:||.|.||||..:.:|||.|:|.|..|....|:      ..:||:|::..  |..
 Worm  1821 LGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRS--VLP 1883

Human   208 EGARKEPLAVVGSPYWMAPEVLR---GELYDEKADVFAFGIVLCELIA-RVP------------- 255
            .|..|   ...|:..:||||::|   .|.|.:|.|.|:||:.|.||:. :.|
 Worm  1884 SGGAK---GFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLD 1945

Human   256 -ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTR-----------AP-FTEI 307
             |.|..||.           ..|:    |.|.|.|.:||.:..|.:|           || ||.:
 Worm  1946 GARPVLLPH-----------ELLL----PTPMLDLLVHCWSAHPESRPSSSQLVGFCAAPEFTHL 1995

Human   308 TQHLEWILEQLPEPAPLTRTALT 330
            ....| :.|.|| |..|....:|
 Worm  1996 LDVCE-LGEALP-PTQLMAVGIT 2016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		8/16 (50%)
		PKc_TESK	63..318	CDD:271057	78/294 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..373		96/348 (28%)
		Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572	419..524
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..488
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572	527..626
		Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572	527..624
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..564
lrk-1	NP_492839.4	ANKYR	13..337	CDD:440430
		ANK repeat	56..88	CDD:293786
		ANK repeat	90..121	CDD:293786
		ANK repeat	197..228	CDD:293786
		ANK repeat	230..262	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	366..472	CDD:463710
		ANK repeat	398..432	CDD:293786
		LRR	<529..>778	CDD:443914
		leucine-rich repeat	534..555	CDD:275380
		leucine-rich repeat	556..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..627	CDD:275380
		leucine-rich repeat	628..654	CDD:275380
		leucine-rich repeat	655..684	CDD:275380
		leucine-rich repeat	687..718	CDD:275380
		leucine-rich repeat	719..742	CDD:275380
		leucine-rich repeat	743..765	CDD:275380
		leucine-rich repeat	803..856	CDD:275380
		LRR	<857..>953	CDD:443914
		leucine-rich repeat	857..883	CDD:275380
		leucine-rich repeat	884..906	CDD:275380
		leucine-rich repeat	907..931	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	977..1160	CDD:476819
		COR	<1239..>1336	CDD:406489
		Protein Kinases, catalytic domain	1699..1990	CDD:473864	85/318 (27%)