DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TEP1 and prp17

DIOPT Version :9

Sequence 1:	NP_009041.2	Gene:	TEP1 / 7011	HGNCID:	11726	Length:	2627	Species:	Homo sapiens
Sequence 2:	NP_001342709.1	Gene:	prp17 / 2541168	PomBaseID:	SPBC6B1.10	Length:	558	Species:	Schizosaccharomyces pombe

Alignment Length:	491	Identity:	102/491 - (20%)
Similarity:	178/491 - (36%)	Gaps:	112/491 - (22%)

- Green bases have known domain annotations that are detailed below.

Human  1580 LLEAHALY----------ASSVPKEEQKLPEADVAVFRTFLRQQASILSQYPRLLPQQAANQPLD 1634
            :||....|          .||.|.|..:..|.:....::....:::.|.| ..||.:|.|...::
pombe   146 ILEGDGAYKGPWAGYGSEQSSSPLEYSEYEEVESLDVKSEKDTESNNLGQ-NELLKEQLATPEVE 209

Human  1635 SPLCHQASLLSRRWHLQHTLRWLNKPRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGT 1699
            :   |::.        :.|:  |:|.|....|..|.:.:     |..|..:.:.:     ....|
pombe   210 T---HRSK--------EETI--LHKDRLFDYQNRSYMHV-----PNDVGINLSEE-----PGEQT 251

Human  1700 VYL--LDLRTWQEEKSVVSGCDGISACLF--LSDDTLFLTAFDGLLELWDLQHGCRVLQT-KAHQ 1759
            .|:  ..:.||:....      |||...|  :|...|...:.|..:::|::.|...:|:| :.|.
pombe   252 CYIPKKHIFTWKGHTK------GISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHA 310

Human  1760 YQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSI 1824
            ..|.....|.|.|...:......:|||||..|:........:..|||.
pombe   311 RPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVK----------------- 358

Human  1825 SFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAA 1889
              ||||..|..:.| |..|..|.|.|::        |...:|:           |:..|.|.:.:
pombe   359 --FQVDPDKPNEFL-AGTADKRILQFDI--------RSPDIVQ-----------AYDHHLGGINS 401

Human  1890 ALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAV---------- 1944
            ..||..|.:.:|..:|..::.|......|...:..:::.....|||.|:|..:|.
pombe   402 ITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVY 466

Human  1945 ----GYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL 2005
                .||.:..:::|    .....|.:|:|..|.    ..:.:.||...|:...|..|.|.|.:
pombe   467 SAYEKYRQNKKKVFK----GYSCSGYSLEVGFSP----DGRFVFSGDSSGNACFWDWKTCKLMA- 522

Human  2006 WLLSRFQKPVLGLA----TSQELLASASEDFTVQLW 2037
             .|.....||..:|    .:.::..|:..|.:::.|
pombe   523 -KLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYW 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEP1	NP_009041.2	TEP1 N-terminal 1	1..30
		TEP1_N	1..29	CDD:283129
		TEP1 N-terminal 2	31..60
		TEP1_N	31..59	CDD:283129
		TEP1 N-terminal 3	61..90
		TEP1_N	61..89	CDD:283129
		TEP1 N-terminal 4	91..120
		TEP1_N	91..119	CDD:283129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..214
		TROVE	226..676	CDD:283406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..402
		DUF4062	908..1008	CDD:290011
		NACHT	1162..1337	CDD:283404
		WD 1	1411..1448
		WD 2	1674..1713		6/40 (15%)
		WD40	1680..1955	CDD:295369	61/293 (21%)
		WD40	<1680..1824	CDD:225201	30/148 (20%)
		WD40 repeat	1680..1716	CDD:293791	5/37 (14%)
		WD 3	1716..1754		9/39 (23%)
		WD40 repeat	1722..1757	CDD:293791	9/37 (24%)
		WD 4	1757..1796		11/38 (29%)
		WD40 repeat	1762..1801	CDD:293791	10/38 (26%)
		WD 5	1798..1837		8/38 (21%)
		WD40	1799..2190	CDD:225201	53/257 (21%)
		WD40 repeat	1804..1840	CDD:293791	9/35 (26%)
		WD 6	1840..1879		7/38 (18%)
		WD40 repeat	1845..1881	CDD:293791	6/35 (17%)
		WD 7	1882..1921		9/38 (24%)
		WD40 repeat	1888..1923	CDD:293791	7/34 (21%)
		WD 8	1925..1964		9/52 (17%)
		WD 9	1967..2005		10/37 (27%)
		WD40	1972..2308	CDD:238121	15/70 (21%)
		WD40 repeat	1972..2013	CDD:293791	9/40 (23%)
		WD 10	2008..2047		7/34 (21%)
		WD40 repeat	2016..2059	CDD:293791	4/26 (15%)
		WD40	2022..2391	CDD:225201	3/16 (19%)
		WD 11	2059..2098
		WD40 repeat	2064..2103	CDD:293791
		WD 12	2105..2143
		WD40 repeat	2111..2145	CDD:293791
		WD 13	2146..2183
		WD40 repeat	2151..2235	CDD:293791
		WD 14	2185..2233
		WD40	2231..>2391	CDD:295369
		WD 15	2236..2275
		WD40 repeat	2241..2280	CDD:293791
		WD 16	2278..2317
		WD40 repeat	2283..2307	CDD:293791
		WD 17	2319..2355
		WD40 repeat	2326..2359	CDD:293791
		WD 18	2368..2417
		WD40 repeat	2372..2418	CDD:293791
		WD 19	2459..2500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2506..2551
		WD 20	2553..2590
		WD 21	2592..2626
prp17	NP_001342709.1	WD40	258..558	CDD:238121	77/355 (22%)
		WD40 repeat	269..308	CDD:293791	10/38 (26%)
		WD40 repeat	314..349	CDD:293791	9/34 (26%)
		WD40 repeat	354..393	CDD:293791	17/77 (22%)
		WD40 repeat	400..435	CDD:293791	7/34 (21%)
		WD40 repeat	442..481	CDD:293791	8/38 (21%)
		WD40 repeat	489..525	CDD:293791	10/41 (24%)
		WD40 repeat	531..557	CDD:293791	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910