DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TEK and Dscam1

DIOPT Version :9

Sequence 1:	NP_000450.3	Gene:	TEK / 7010	HGNCID:	11724	Length:	1124	Species:	Homo sapiens
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	167/769 - (21%)
Similarity:	264/769 - (34%)	Gaps:	163/769 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    42 LTCIASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRV 106
            |.|:|.| .|...|:...|.:.:.|  .|..:|.|.||                          |
  Fly   452 LKCVAGG-NPTPEISWELDGKKIAN--NDRYQVGQYVT--------------------------V 487

Human   107 RGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNG-SFIHSVPRHEV 170
            .|:.:           |:|..|.....|.|....|:..||.:.|..|.:...| .:|..:.:..:
  Fly   488 NGDVV-----------SYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAI 541

Human   171 --PDILEVHLPHA-QPQDAGVYSA--RYIGGNLFTSAFTR--LIVRRCEAQKWGPECNHLCTACM 228
              .:.|.|..|.| .|.|:.|:..  |.:..|.....|..  ||:...|..  ..:..:.|.|..
  Fly   542 VAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERN--SDQATYTCVAKN 604

Human   229 NNGVCHEDTGEC-------ICPPGF-----MGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCL 281
            ..|.....:.|.       |.|..:     ||.:.:..|::....|..|...|.:.....|.|..
  Fly   605 QEGYSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQ 669

Human   282 PDPYGCSCATGWKGLQCNE-----------ACHPGFYGPDCKLRCSCNNGEMCDRFQGCL---CS 332
            ..|.          ::.|.           :..|...|.|   .|..:|......:...|   ..
  Fly   670 VQPQ----------MRTNRISEKTSMISIPSASPAHTGRD---TCIASNKAGTTTYSVDLTVNVP 721

Human   333 PGWQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDG-TVLHPK 396
            |.|                |::..|............|||.|:|.|   ::|..|..| |....|
  Fly   722 PRW----------------ILEPTDKAFAQGSDAKVECKADGFPKP---QVTWKKAVGDTPGEYK 767

Human   397 DFNHTDHFSVAIFTIH--RILPPDSGVWVC-SVNTVAGMVEKPFNISVKVLPK-PLNAPNVIDTG 457
            |...:|:..|...|:|  .|...:.|.::| ::|.:...:.....|||:..|: .....|.....
  Fly   768 DLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARR 832

Human   458 HNFAVINISSEPYFGDGPI------KSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYE-- 514
            ...||:...::   |:.||      .:.:|..|..|.|...:.|..|..:.:|:.  .|||..
  Fly   833 GEPAVLQCEAK---GEKPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSI--KRTERSDS 892

Human   515 ---LCVQLVRRGEGGEGHPGPVRRFTTASIGL------PPPRGLNLLPKSQTTLNLTW-QPIFPS 569
               .||.....|.            ..|||.:      ..|..|.:|.||..::.|:| ||...:
  Fly   893 ALFTCVATNAFGS------------DDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGN 945

Human   570 SE-DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVR-ARVNTKAQGEWSEDLTAW 632
            |. |.:.:|.:|.....|:...:.|||:.|...:..|.|...|.:| ...|.....:.||.:|..
  Fly   946 SPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTII 1010

Human   633 TLSDILPPQPENIKISNITHSSAVISW-----TILDGYSISSITIRYKVQGKNED---QHVDVKI 689
            |..:....:|:|||:..:..::..::|     |..:| .|....:.||:...|..   :.::...
  Fly  1011 TAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNG-EILGYYVGYKLSNTNSSYVFETINFIT 1074

Human   690 KNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPE---SQAPAD 740
            :.......:|:.|...|.|.|.|.|.|.|| :.|....|.....|   ||.|:|
  Fly  1075 EEGKEHNLELQNLRVYTQYSVVIQAFNKIG-AGPLSEEEKQFTAEGTPSQPPSD 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEK	NP_000450.3	Ig_Tie2_1	24..118	CDD:402176	15/75 (20%)
		EGF_Lam	230..275	CDD:238012	10/56 (18%)
		EGF_Lam	314..>342	CDD:238012	5/30 (17%)
		IgI_Tie2	348..439	CDD:409556	22/94 (23%)
		Ig strand B	366..370	CDD:409556	0/3 (0%)
		Ig strand C	382..386	CDD:409556	1/3 (33%)
		Ig strand E	407..411	CDD:409556	0/3 (0%)
		Ig strand F	421..426	CDD:409556	1/5 (20%)
		Ig strand G	434..437	CDD:409556	0/2 (0%)
		fn3	445..520	CDD:394996	19/86 (22%)
		fn3	544..626	CDD:394996	23/84 (27%)
		FN3	639..731	CDD:238020	23/99 (23%)
		PTKc_Tie2	816..1118	CDD:133219
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	25/114 (22%)
		IGc2	446..517	CDD:197706	22/104 (21%)
		I-set	533..618	CDD:254352	18/86 (21%)
		IGc2	544..607	CDD:197706	15/64 (23%)
		Ig	641..714	CDD:143165	13/85 (15%)
		IGc2	735..804	CDD:197706	20/71 (28%)
		I-set	819..914	CDD:254352	23/111 (21%)
		Ig	833..921	CDD:299845	21/104 (20%)
		FN3	918..1011	CDD:238020	26/92 (28%)
		FN3	1018..1116	CDD:238020	23/99 (23%)
		FN3	1124..1217	CDD:238020	2/4 (50%)
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910