DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TEK and Tek

DIOPT Version :9

Sequence 1:	NP_000450.3	Gene:	TEK / 7010	HGNCID:	11724	Length:	1124	Species:	Homo sapiens
Sequence 2:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus

Alignment Length:	1125	Identity:	1044/1125 - (92%)
Similarity:	1081/1125 - (96%)	Gaps:	3/1125 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALM 65
            |||||.||||||||||.|.||||||||||||||||||||||||||||||.|||||||||||||||
Mouse     1 MDSLAGLVLCGVSLLLYGVVEGAMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALM 65

Human    66 NQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLT 130
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Mouse    66 NQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLT 130

Human   131 MTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIG 195
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 MTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIG 195

Human   196 GNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTF 260
            |||||||||||||||||||||||:|:..||.|.||||||||||||||||||||||||||||.|||
Mouse   196 GNLFTSAFTRLIVRRCEAQKWGPDCSRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTF 260

Human   261 GRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDR 325
            ||||||||||.||||||||||||||||||||||:||||||||..|:|||||||||.|.|.|:|||
Mouse   261 GRTCKERCSGPEGCKSYVFCLPDPYGCSCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDR 325

Human   326 FQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDG 390
            |||||||.||||||||:||..||||:|.||||||||||||||||||||||||||:||||||||||
Mouse   326 FQGCLCSQGWQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDG 390

Human   391 TVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVID 455
            |||.|.|||:||.|||||||::|:|||||||||||||||||||||||||||||||:||:||||||
Mouse   391 TVLQPNDFNYTDRFSVAIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVID 455

Human   456 TGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLV 520
            ||||||:|||||||||||||||||||.|||||  :||::|:|||||.|||||||||:|||||||.
Mouse   456 TGHNFAIINISSEPYFGDGPIKSKKLFYKPVN--QAWKYIEVTNEIFTLNYLEPRTDYELCVQLA 518

Human   521 RRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQ- 584
            |.|||||||||||||||||||||||||||:|||||||.|||||||||.:|||:|||||||||:|
Mouse   519 RPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFTNSEDEFYVEVERRSLQT 583

Human   585 KSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISN 649
            .|||||||||||||||||:||.|||||.|||||||||||||||:|.|||||||||||||||||||
Mouse   584 TSDQQNIKVPGNLTSVLLSNLVPREQYTVRARVNTKAQGEWSEELRAWTLSDILPPQPENIKISN 648

Human   650 ITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFA 714
            ||.|:|::||||:||||||||.|||||||||||||:||||||||:||||||||||||.|.|||||
Mouse   649 ITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVKIKNATVTQYQLKGLEPETTYHVDIFA 713

Human   715 ENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQR 779
            |||||||||||||||.|||.|.|.|||||||||||||||||||||:||||||||:||||||||||
Mouse   714 ENNIGSSNPAFSHELRTLPHSPASADLGGGKMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQR 778

Human   780 RMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIK 844
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   779 RMAQAFQNVREEPAVQFNSGTLALNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIK 843

Human   845 KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 909
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   844 KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGN 908

Human   910 LLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE 974
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   909 LLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE 973

Human   975 NYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY 1039
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   974 NYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY 1038

Human  1040 CGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVN 1104
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1039 CGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVN 1103

Human  1105 TTLYEKFTYAGIDCSAEEAA 1124
            ||||||||||||||||||||
Mouse  1104 TTLYEKFTYAGIDCSAEEAA 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEK	NP_000450.3	Ig_Tie2_1	24..118	CDD:402176	91/93 (98%)
		EGF_Lam	230..275	CDD:238012	42/44 (95%)
		EGF_Lam	314..>342	CDD:238012	22/27 (81%)
		IgI_Tie2	348..439	CDD:409556	80/90 (89%)
		Ig strand B	366..370	CDD:409556	3/3 (100%)
		Ig strand C	382..386	CDD:409556	3/3 (100%)
		Ig strand E	407..411	CDD:409556	3/3 (100%)
		Ig strand F	421..426	CDD:409556	4/4 (100%)
		Ig strand G	434..437	CDD:409556	2/2 (100%)
		fn3	445..520	CDD:394996	62/74 (84%)
		fn3	544..626	CDD:394996	71/82 (87%)
		FN3	639..731	CDD:238020	81/91 (89%)
		PTKc_Tie2	816..1118	CDD:133219	300/301 (100%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411	91/93 (98%)
		EGF_Lam	230..275	CDD:238012	42/44 (95%)
		EGF_2	311..340	CDD:285248	23/28 (82%)
		fn3	445..516	CDD:278470	60/72 (83%)
		fn3	542..625	CDD:278470	71/82 (87%)
		FN3	638..730	CDD:238020	81/91 (89%)
		PTKc_Tie2	815..1117	CDD:133219	300/301 (100%)
		STYKc	823..1091	CDD:214568	266/267 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952362
Domainoid	1	1.000	656	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_KOG0200
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H397
Inparanoid	1	1.050	2153	1.000	Inparanoid score	I1336
Isobase	1	0.950	-	0	Normalized mean entropy	S658
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43836
OrthoDB	1	1.010	-	-		D16053at40674
OrthoFinder	1	1.000	-	-		FOG0011663
OrthoInspector	1	1.000	-	-		oto116413
orthoMCL	1	0.900	-	-		OOG6_106288
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9931
SonicParanoid	1	1.000	-	-		X9382
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	20	20.250