DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TECTA and HPF1

DIOPT Version :9

Sequence 1:	NP_005413.2	Gene:	TECTA / 7007	HGNCID:	11720	Length:	2155	Species:	Homo sapiens
Sequence 2:	NP_014487.1	Gene:	HPF1 / 854010	SGDID:	S000005515	Length:	967	Species:	Saccharomyces cerevisiae

Alignment Length:	735	Identity:	147/735 - (20%)
Similarity:	218/735 - (29%)	Gaps:	253/735 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   157 GSSTTPVNTFQAVLVSDGSYTFTLFNYYEIN----WTTGTASGGDPLTGLGGVMAQAGFN---GG 214
            ||.|:  .|..::..|..|.|.|..|....:    :...|...|| :|..|.|:|.....   ||
Yeast   301 GSITS--GTLSSITSSASSATATASNSLSSSDGTIYLPSTTISGD-ITLTGSVIATEAVEVAAGG 362

Human   215 NLTNFFSLPGSR----TPEIVN---IQETTNVNVPGRWAFKVDGKEID---------PANGCTSR 263
            .||   .|.|.:    ...|::   ..|.:....||. .|.:.|:..|         ||....|.
Yeast   363 KLT---LLDGDKYVFSADFIIHGGVFVEKSKPTYPGT-EFDISGENFDVSGTFNAEEPAASSASA 423

Human   264 -----GQFLRRGEVFWDDLNCTVKCRCLDFNNEIYCQEASCSPYEVCEPKGKFFYCSAV------ 317
                 |.|...|     |::.::        :|....|.:.|||   ...|.|.:.:|:
Yeast   424 YSFTPGSFDNSG-----DISLSL--------SESTKGEVTFSPY---SNSGAFSFSNAILNGGSV 472

Human   318 -------------------ETSTCVVFGEP----------------HY-HTFDGFLFHFQGSCAY 346
                               |..:..|..||                || .||.|....|:|.  .
Yeast   473 SGLQRRAESGSVNNGEINLENGSTYVVVEPVSGSGTINIISGNLYLHYPDTFTGQTVVFKGE--G 535

Human   347 LLARQCLQTSSLPFFSVEAKNEHRRGSAVSWVKELSVEVNGYKILIPKGSYGRVKVNDLVTSLPV 411
            :||....:|::.|                       :.|.||.      ...::.:...||:|..
Yeast   536 VLAVDPTETNTTP-----------------------IPVVGYT------GENQIAITADVTALSY 571

Human   412 TLDLGTVKIYQ--SGISTAVETDF---GLLV---TFDGQH-----YASISVPGSYINSTCGLCGN 463
            ....|.:...|  |..|.::.|.|   |..|   ||.|.:     |..:....:..:||....|.
Yeast   572 DSATGVLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSATPSSTSTTSGA 636

Human   464 YNKNPLDDFLRPDGRPAMSVLDLGESWRVYHADWKCDSGCVDNCTQCDAATEALYFGSDYCGFLN 528
            .|..                                 ||..........:|.:..||:...|
Yeast   637 TNST---------------------------------SGSTSFGASVTGSTASTSFGASVTG--- 665

Human   529 KTDGPLWECGTVVDPTAFVH----SCVYDLCS--VRDNG-------TLLCQAIQAYALVCQALGI 580
            .|...|......|..|...:    |.|...||  ...||       |:.|.:..|....|...|.
Yeast   666 STASTLISGSPSVYTTTLTYATTTSTVVVSCSETTDSNGNVYTITTTVPCSSTTATITSCDETGC 730

Human   581 PIGDWRTQTGCVSTVQCPSFSHYSV---------C-----TSSCP-DTCSDLTASRNCATPCTEG 630
            .:   .|.||.|:|....|.|:.:|         |     ||.|| :|.:..|:.::..|.....
Yeast   731 HV---TTSTGTVATETVSSKSYTTVTVTHCDNNGCNTKTVTSECPEETSATTTSPKSYTTVTVTH 792

Human   631 CE---CNQGFVLSTSQCVPLHKCGCDFDGHYYTMGEFFWATANCTVQCLCEEGGDVYCFNKTCGS 692
            |:   ||...|.|.:.           :....|:....:.||..|   .|::.|   |..||..|
Yeast   793 CDDNGCNTKTVTSEAP-----------EATTTTVSPKTYTTATVT---QCDDNG---CSTKTVTS 840

Human   693 ---------GEVCAVEDGYQGCFPKRETVCLLSQ------------NQVLHTFDGASYAFPSEFS 736
                     .|..|.        ||..|...::|            :|:.......:....|..|
Yeast   841 EAPKETSETSETSAA--------PKTYTTATVTQCDDNGCNVKIITSQIPEATSTVTATSASPKS 897

Human   737 YTLLKTCPERPEYLEIDINK 756
            ||.:.:...:...|...|:|
Yeast   898 YTTVTSEGSKATSLTTAISK 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TECTA	NP_005413.2	NIDO	98..254	CDD:214712	28/110 (25%)
		VWD	322..478	CDD:278521	36/185 (19%)
		C8	517..591	CDD:214843	20/86 (23%)
		TIL	597..650	CDD:280072	16/70 (23%)
		VWC	652..706	CDD:302663	12/62 (19%)
		VWD	703..865	CDD:214566	12/66 (18%)
		C8	905..981	CDD:214843
		TIL	984..1036	CDD:280072
		VWD	1100..1258	CDD:278521
		C8	1298..1368	CDD:285899
		TIL	1372..1425	CDD:280072
		VWD	1487..1639	CDD:278521
		C8	1684..1757	CDD:214843
		ZP	1805..2057	CDD:214579
		Zona_pellucida	1937..2057	CDD:278526
		FXa_inhibition	2089..2121	CDD:291342
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	67/331 (20%)
HPF1	NP_014487.1	Herpes_BLLF1	<643..937	CDD:282904	64/306 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900