DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TEAD3 and sd

DIOPT Version :9

Sequence 1:	NP_001382143.1	Gene:	TEAD3 / 7005	HGNCID:	11716	Length:	435	Species:	Homo sapiens
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	247/436 - (56%)
Similarity:	295/436 - (67%)	Gaps:	88/436 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    13 GEAREDGPEGLDKGLDN-DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARY 76
            |:..:|     :|.|.: ||||||||||||||||||:||||||||||||||||||||||||||||
  Fly    75 GDMSDD-----EKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYGRNELIARY 134

Human    77 IKLRTGKTRTRKQVSSHLQVLARRKSREIQSKLKAMNLDQVSKDKALQSMASMSSAQIVSASVLQ 141
            |||||||||||||||||:|||||||.||||:|:|.
  Fly   135 IKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKV------------------------------ 169

Human   142 NKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPI----------QPPLPPTL 196
                              :||..    |.||..|||||||.||.||.          :..:||
  Fly   170 ------------------QFWQP----GLQPSTSQDIKPFPQPPYPAGKTSTAVSGDETGIPP-- 210

Human   197 SSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDP 261
                  :.||        |:.|.||:.:.||||::||||:||| :.|.:||||.:| ..|:||||
  Fly   211 ------SQLP--------WEGRAIATHKFRLLEFTAFMEIQRD-EIYHRHLFVQLG-GKPSFSDP 259

Human   262 PLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEG--PGAFYGVSSQYSSA 324
            .||.||:|||:||||||.||||:||||||.|||:|||.|||||:.:..|  .|.||||:|||.|.
  Fly   260 LLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTDLTTGSETGDFYGVTSQYESN 324

Human   325 DSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNS 389
            :::.:..||.|||||||||||||:||:||||.|:||||.||||||||||||.|||:|||:|||||
  Fly   325 ENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNS 389

Human   390 VLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD 435
            ||||||||||:.:|::|||||.||:||||:....|..||:|:|:|:
  Fly   390 VLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEAD3	NP_001382143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		7/21 (33%)
TEAD3	NP_001382143.1	Transcriptional activation. /evidence=ECO:0000255	173..435		161/273 (59%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	64/66 (97%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	141/209 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157341
Domainoid	1	1.000	300	1.000	Domainoid score	I1421
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1525
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm41891
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2507
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800