DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TEAD4 and sd

DIOPT Version :9

Sequence 1:	NP_003204.2	Gene:	TEAD4 / 7004	HGNCID:	11717	Length:	434	Species:	Homo sapiens
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	266/450 - (59%)
Similarity:	305/450 - (67%)	Gaps:	75/450 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     6 GTITSNEW----SSPTSPEGSTASGGSQALDKPID-------------NDAEGVWSPDIEQSFQE 53
            |||.| .|    :.|....||..:.||....|.:|             .||||||||||||||||
  Fly    40 GTIPS-PWTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQE 103

Human    54 ALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLK 118
            ||:|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||:|
  Fly   104 ALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIK 168

Human   119 DQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPG-QAGTSHDVKPFSQ 182
            .|                                         |||   || |..||.|:|||.
  Fly   169 VQ-----------------------------------------FWQ---PGLQPSTSQDIKPFP- 188

Human   183 QTYAVQPPLPLPGFESPAGPAPSPSAPPAP-PWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHL 246
                 |||.| .|..|.|........||:. ||:||::|:.|..:|||:||:|.|:| :.|::||
  Fly   189 -----QPPYP-AGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTAFMEIQRD-EIYHRHL 246

Human   247 FVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIE--DE 309
            ||.:| ..||:|||.||.||||||:||||||.||||||:|:||.|||:|||.||||||::.  .|
  Fly   247 FVQLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTDLTTGSE 310

Human   310 GSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFI 374
            ...||||:|||||.||:::.|||.|||||||||||||:||:|.||..|.|||.|||:||||||||
  Fly   311 TGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINFI 375

Human   375 HKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE 434
            .|||:|||:|||||||||||||||:..|:||||||||||||||:|...|..||||||:||
  Fly   376 QKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEAD4	NP_003204.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		15/52 (29%)
		TEA	38..105	CDD:128703	65/66 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..215		10/27 (37%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	145/209 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157340
Domainoid	1	1.000	300	1.000	Domainoid score	I1421
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1525
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm41891
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	LDO	PTHR11834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2507
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800