DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TEAD1 and sd

DIOPT Version :9

Sequence 1:	NP_068780.2	Gene:	TEAD1 / 7003	HGNCID:	11714	Length:	426	Species:	Homo sapiens
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	257/448 - (57%)
Similarity:	303/448 - (67%)	Gaps:	79/448 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     3 PSSW----------------SGSESPAENME--RMSDSADKPIDNDAEGVWSPDIEQSFQEALAI 49
            ||.|                :||...::|::  .|||........||||||||||||||||||:|
  Fly    43 PSPWTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSI 107

Human    50 YPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTA 114
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.|:..:|:|.|
  Fly   108 YPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQ-- 170

Human   115 KDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFW-PGMIQTGQPGSSQDVKPFVQQ 178
                                                     || ||:    ||.:|||:|||.|.
  Fly   171 -----------------------------------------FWQPGL----QPSTSQDIKPFPQP 190

Human   179 AYP---IQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFV 240
            .||   ...||:....|..|:..|      |:||:|.|.|.||:||:||:|.||| :.|::||||
  Fly   191 PYPAGKTSTAVSGDETGIPPSQLP------WEGRAIATHKFRLLEFTAFMEIQRD-EIYHRHLFV 248

Human   241 HIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQ--DDAG 303
            .:| ...|:||||||:||||||:||||||.||||:|:.|||||||:|||.|||||.::.  .:.|
  Fly   249 QLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTDLTTGSETG 312

Human   304 AFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHK 368
            .||||||||||:||:.:.|||.|||||||||||||:||:|.||.|:||||.||||||||||||.|
  Fly   313 DFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINFIQK 377

Human   369 LKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD 426
            ||:|||:|||||||||||||.|:..|:|||||||:|.||||:....|..||||||:|:
  Fly   378 LKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TEAD1	NP_068780.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		9/45 (20%)
		TEA	30..97	CDD:128703	65/66 (98%)
		Transcriptional activation. /evidence=ECO:0000255	167..426		166/263 (63%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	145/209 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157342
Domainoid	1	1.000	300	1.000	Domainoid score	I1421
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2418
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1525
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm41891
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2507
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800