DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTN1A1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001723.2	Gene:	BTN1A1 / 696	HGNCID:	1135	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	235	Identity:	48/235 - (20%)
Similarity:	88/235 - (37%)	Gaps:	36/235 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    30 DVIGPPEPILAVVGEDAELPCRLSPNASAEHLELRWFRKKVSPAVLVHRDGREQEAEQMPEYRGR 94
            |||   |.|....|.:.:|.|.:....|   .::.|...:.|..:.||        ..:.....|
  Fly    56 DVI---ENITVPAGRNVKLACSVKNLGS---YKVAWMHFEQSAILTVH--------NHVITRNPR 106

Human    95 ATLVQDGIAKGRV-ALRIRGVRVSDDGEYTCFF-----REDGSYEEALV--HLKVAALGSDPHIS 151
            .::..|...|.|. .|.|..|:..|.|.|.|..     :....:.:.:|  ::..|...||
  Fly   107 ISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSD---- 167

Human   152 MQVQENGEICLECTSVGWYPEPQVQWRTSKGEKFPSTSESRNPDEEGLFTVAASVIIRDTSAKNV 216
            :.|:|...:.|.|.:.| .|||.::|:...|.|..........|.|     ..|:.:...|..::
  Fly   168 IIVREGDNVTLRCKAKG-SPEPTIKWKRDDGNKIVINKTLEVHDLE-----TDSLELERISRLHM 226

Human   217 SCYI----QNLLLGQEKKVEISIPASSLPRLTPWIVAVAV 252
            ..|:    ..:.....|::::|:..|.:..:...:|.:.:
  Fly   227 GAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPI 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN1A1	NP_001723.2	IG_like	35..141	CDD:214653	22/113 (19%)
		Ig_MOG_like	43..142	CDD:143190	20/106 (19%)
		Ig	162..223	CDD:299845	14/64 (22%)
		SPRY_PRY_BTN1_2	302..473	CDD:293991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..526
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/106 (20%)
		Ig	69..139	CDD:143165	18/80 (23%)
		IG_like	165..249	CDD:214653	19/93 (20%)
		IGc2	172..237	CDD:197706	15/70 (21%)
		IG_like	267..348	CDD:214653	48/235 (20%)
		Ig	270..339	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910