DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTN1A1 and ed

DIOPT Version :9

Sequence 1:	NP_001723.2	Gene:	BTN1A1 / 696	HGNCID:	1135	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster

Alignment Length:	277	Identity:	55/277 - (19%)
Similarity:	89/277 - (32%)	Gaps:	67/277 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     2 AVFPSSGLPRCLLTL---ILLQLPKLDSAPFDVIGPPEPILAVVGEDAELPCRLSPNASAEHLEL 63
            |:..|....|...|:   .|:.|..|.|...    ..|.|......|..|.||.:....|.....
  Fly    11 AIVNSRSARRAATTICNFFLIALVALSSTTL----ADESIDTRENADLTLKCRFNDKYEANDFSF 71

Human    64 RWFRKKVSPAVLVHRDGREQEAEQMPEYRGRATLVQDGIAKGRVALRIRGVRVS---DDGEY--- 122
            .|.|...:||..                        |.:|.|.|.|. .|.|:.   :.|.|
  Fly    72 FWTRWTANPAQF------------------------DNVAIGEVQLS-SGYRLDFQPERGIYDLQ 111

Human   123 ---TCFFREDGSYEEALVHLKVAALGSDPHISMQ-----------VQENGEIC---------LEC 164
               ..:.|::|.:|   ..:|....|:|.|....           |...|.|.         |.|
  Fly   112 IKNVSYNRDNGRFE---CRIKAKGTGADVHQEFHNLTVLTPPHPPVISPGNIAVATEDKPMELTC 173

Human   165 TSVGWYPEPQVQW-RTSKGEKFPSTSESRNPDEEGLFTVAASVIIRDTSAKNVSCYIQNLLLGQE 228
            :|:|..|:|.:.| |.......|:|.......::......:.:..|:.......|.::|..:.:.
  Fly   174 SSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEG 238

Human   229 KKVE--ISIPASSLPRL 243
            |::|  .::..:..||:
  Fly   239 KRLEATATLNVNYYPRV 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN1A1	NP_001723.2	IG_like	35..141	CDD:214653	23/114 (20%)
		Ig_MOG_like	43..142	CDD:143190	22/107 (21%)
		Ig	162..223	CDD:299845	12/61 (20%)
		SPRY_PRY_BTN1_2	302..473	CDD:293991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..526
ed	NP_001260013.1	Ig	50..147	CDD:299845	25/124 (20%)
		I-set	146..249	CDD:254352	18/102 (18%)
		Ig	168..249	CDD:299845	15/80 (19%)
		IGc2	268..323	CDD:197706
		Ig_3	341..406	CDD:290638
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910