DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTK and HSE1

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_011861.1	Gene:	HSE1 / 856387	SGDID:	S000000994	Length:	452	Species:	Saccharomyces cerevisiae

Alignment Length:	271	Identity:	62/271 - (22%)
Similarity:	96/271 - (35%)	Gaps:	71/271 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   215 HRKTKKPLPPTPEEDQILKKPLPPE----------PAAAPVSTSELKKVVALYDYMPMNANDLQL 269
            :.|.||    ..|:::...:.||.:          ||....:.:.:::|.||||......::|..
Yeast   178 YEKQKK----LQEQEKESAEVLPQQQQQHQQQNQAPAHKIPAQTVVRRVRALYDLTTNEPDELSF 238

Human   270 RKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTE-AEDSIEMYE--------WYSKHMTRSQA 325
            ||||...:||:....||:.. ..|..|..|.||||. .|.|.|..|        .:|:..|..|.
Yeast   239 RKGDVITVLEQVYRDWWKGA-LRGNMGIFPLNYVTPIVEPSKEEIEKEKNKEAIVFSQKTTIDQL 302

Human   326 EQLLKQEGKEGGF--IVRD-----------------SSKAGKYTVSVFAKSTGDPQGVIRHYVVC 371
            ...|....|.|..  :::|                 :...|||     ||...|...:  ..|:.
Yeast   303 HNSLNAASKTGNSNEVLQDPHIGDMYGSVTPLRPQVTRMLGKY-----AKEKEDMLSL--RQVLA 360

Human   372 STPQSQYYL----AEKHLFSTIPELINY----HQHNSAGL-ISRLKY------------PVSQQN 415
            :..:|...|    |..|:...:|....|    |.:|:..: ..|..|            |:....
Yeast   361 NAERSYNQLMDRAANAHISPPVPGPALYAGMTHANNTPVMPPQRQSYQSNEYSPYPSNLPIQHPT 425

Human   416 KNAPSTAGLGY 426
            .:|.:|...||
Yeast   426 NSANNTPQYGY 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	20/53 (38%)
		SH2_Tec_Btk	308..413	CDD:198260	28/152 (18%)
		PTKc_Btk_Bmx	431..686	CDD:173657
		Pkinase_Tyr	436..685	CDD:285015
HSE1	NP_011861.1	VHS_HSE1	8..140	CDD:340775
		SH3_GRB2_like_C	221..273	CDD:212739	20/52 (38%)
		GAT_Hse1	290..374	CDD:410591	16/90 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910