DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTK and PIN3

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_015480.1	Gene:	PIN3 / 856277	SGDID:	S000006358	Length:	215	Species:	Saccharomyces cerevisiae

Alignment Length:	207	Identity:	57/207 - (27%)
Similarity:	80/207 - (38%)	Gaps:	37/207 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   229 DQILKKPLPP--EPAAAP--VSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRAR 289
            ||| .|.||.  :||.||  .|.:.|:.|.|||.:.|....||.|:.||:..:||:.:..|::.
Yeast    32 DQI-NKSLPAKWDPANAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKG- 94

Human   290 DKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVF 354
            ..||:.|..|:|||..|         :|.....|......:.:.:|...|...:|.|..|....|
Yeast    95 SCNGRTGIFPANYVKPA---------FSGSNGPSNLPPPPQYKAQELQQIPTQNSAASSYQQQPF 150

Human   355 AKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIP---ELINYHQHNSAGLISRLKYPVSQQNK 416
                             ..|.:.||...:......|   :.....||.|:.  |.||...|:...
Yeast   151 -----------------PPPSTNYYQQPQQQPQQAPPPQQQQQQQQHQSSH--SHLKSFGSKLGN 196

Human   417 NAPSTAGLGYGS 428
            .|...||...||
Yeast   197 AAIFGAGASIGS 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	20/53 (38%)
		SH2_Tec_Btk	308..413	CDD:198260	18/107 (17%)
		PTKc_Btk_Bmx	431..686	CDD:173657
		Pkinase_Tyr	436..685	CDD:285015
PIN3	NP_015480.1	SH3	58..110	CDD:418401	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000