DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTK and PKH2

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_014541.1	Gene:	PKH2 / 854053	SGDID:	S000005460	Length:	1081	Species:	Saccharomyces cerevisiae

Alignment Length:	534	Identity:	106/534 - (19%)
Similarity:	199/534 - (37%)	Gaps:	161/534 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   204 NRNGSLKPGSSHRKTKKPLPPTPEE----DQILKKP----LPP--EPAAAPV-STSELKKVVALY 257
            :::.|:.|        :||.|:.|:    :.:.||.    |.|  :..|.|. |||.
Yeast     4 DKDNSMSP--------RPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSN-------- 52

Human   258 DYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTR 322
                .|..||.|.|.....:::::                     :|..::.||||.   ....:
Yeast    53 ----RNVGDLLLEKRTAKPMIQKA---------------------LTNTDNFIEMYH---NQQRK 89

Human   323 SQAEQLLKQE--GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHL 385
            :..:..:|:.  ..|.|..|. |:..|:|..........|.:.:..   :..:|..:....:..:
Yeast    90 NLDDDTIKEVMINDENGKTVA-STNDGRYDNDYDNNDINDQKTLDN---IAGSPHMEKNRNKVKI 150

Human   386 FSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPST---AGLGYGSWEIDPKDLTFLKELGTGQF 447
                       :|:|:.     :.|:::::..|...   .|:         ||..|...:|.|.:
Yeast   151 -----------EHDSSS-----QKPIAKESSKAQKNIIKKGI---------KDFKFGSVIGDGAY 190

Human   448 GVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEK-----------LVQLYGVCTKQ 501
            ..|....     .:..|......:...|::...|.:..:|.||           :|:|:.....:
Yeast   191 STVMLAT-----SIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDE 250

Human   502 RPIFIITEYMANGCLLNYLR------EMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN 560
            ..::.:.||..||..|:.::      |...|:...|::       :|::||.|...:|||:...|
Yeast   251 SSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQII-------DAIDYLHSNGIIHRDIKPEN 308

Human   561 CLVNDQGVVKVSDFGLSRY-------VLDDEYTSSVGSKFPV---RWSPPEVLMYSKFSSKSDIW 615
            .|::.:..:|::|||.::.       |...||..|..||..|   .:..||:|..|....:.|||
Yeast   309 ILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIW 373

Human   616 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTF-- 678
            |||.:::::.: ||.|: :.||.               :|..:||..:.|:.       .|.|
Yeast   374 AFGCILFQMIA-GKPPF-KATNE---------------YLTFQKVMKVQYAF-------TPGFPL 414

Human   679 -------KILLSNI 685
                   |||:.|:
Yeast   415 IIRDLVKKILVKNL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	5/53 (9%)
		SH2_Tec_Btk	308..413	CDD:198260	16/106 (15%)
		PTKc_Btk_Bmx	431..686	CDD:173657	67/291 (23%)
		Pkinase_Tyr	436..685	CDD:285015	64/284 (23%)
PKH2	NP_014541.1	STKc_PDK1	177..443	CDD:270733	67/288 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910