DRSC/TRiP Functional Genomics Resources

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Protein Alignment BTK and PKH2

DIOPT Version :9

Sequence 1:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens
Sequence 2:NP_014541.1 Gene:PKH2 / 854053 SGDID:S000005460 Length:1081 Species:Saccharomyces cerevisiae


Alignment Length:534 Identity:106/534 - (19%)
Similarity:199/534 - (37%) Gaps:161/534 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   204 NRNGSLKPGSSHRKTKKPLPPTPEE----DQILKKP----LPP--EPAAAPV-STSELKKVVALY 257
            :::.|:.|        :||.|:.|:    :.:.||.    |.|  :..|.|. |||.        
Yeast     4 DKDNSMSP--------RPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSN-------- 52

Human   258 DYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTR 322
                .|..||.|.|.....:::::                     :|..::.||||.   ....:
Yeast    53 ----RNVGDLLLEKRTAKPMIQKA---------------------LTNTDNFIEMYH---NQQRK 89

Human   323 SQAEQLLKQE--GKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHL 385
            :..:..:|:.  ..|.|..|. |:..|:|..........|.:.:..   :..:|..:....:..:
Yeast    90 NLDDDTIKEVMINDENGKTVA-STNDGRYDNDYDNNDINDQKTLDN---IAGSPHMEKNRNKVKI 150

Human   386 FSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPST---AGLGYGSWEIDPKDLTFLKELGTGQF 447
                       :|:|:.     :.|:::::..|...   .|:         ||..|...:|.|.:
Yeast   151 -----------EHDSSS-----QKPIAKESSKAQKNIIKKGI---------KDFKFGSVIGDGAY 190

Human   448 GVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEK-----------LVQLYGVCTKQ 501
            ..|....     .:..|......:...|::...|.:..:|.||           :|:|:.....:
Yeast   191 STVMLAT-----SIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDE 250

Human   502 RPIFIITEYMANGCLLNYLR------EMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN 560
            ..::.:.||..||..|:.::      |...|:...|::       :|::||.|...:|||:...|
Yeast   251 SSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQII-------DAIDYLHSNGIIHRDIKPEN 308

Human   561 CLVNDQGVVKVSDFGLSRY-------VLDDEYTSSVGSKFPV---RWSPPEVLMYSKFSSKSDIW 615
            .|::.:..:|::|||.::.       |...||..|..||..|   .:..||:|..|....:.|||
Yeast   309 ILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIW 373

Human   616 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTF-- 678
            |||.:::::.: ||.|: :.||.               :|..:||..:.|:.       .|.|  
Yeast   374 AFGCILFQMIA-GKPPF-KATNE---------------YLTFQKVMKVQYAF-------TPGFPL 414

Human   679 -------KILLSNI 685
                   |||:.|:
Yeast   415 IIRDLVKKILVKNL 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BTKNP_001274273.1 PH 38..167 CDD:278594
PH_Btk 40..200 CDD:269944
SH3_BTK 251..305 CDD:212839 5/53 (9%)
SH2_Tec_Btk 308..413 CDD:198260 16/106 (15%)
PTKc_Btk_Bmx 431..686 CDD:173657 67/291 (23%)
Pkinase_Tyr 436..685 CDD:285015 64/284 (23%)
PKH2NP_014541.1 STKc_PDK1 177..443 CDD:270733 67/288 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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