DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTK and LSB1

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_011652.1	Gene:	LSB1 / 853037	SGDID:	S000003368	Length:	241	Species:	Saccharomyces cerevisiae

Alignment Length:	218	Identity:	51/218 - (23%)
Similarity:	81/218 - (37%)	Gaps:	50/218 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   230 QILKKPLPPE---PAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK 291
            :::...||.:   ...:|.:....:.|.||||:......||.|:.||:..:||:.:..|:|.: .
Yeast    32 ELINSKLPEKWDGNQRSPQNADTEEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGK-S 95

Human   292 NGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-------SKAGKY 349
            |.:.|..|:|||..|             .|||.:.:  ..|......:.|.|       ..|.:|
Yeast    96 NNKIGIFPANYVKPA-------------FTRSASPK--SAEAASSSTVSRPSVPPPSYEPAASQY 145

Human   350 TVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKY-PVSQ 413
            .....:.....|.|    |:....||.|     :......|...||:|.      .:.:| |.||
Yeast   146 PSQQVSAPYAPPAG----YMQAPPPQQQ-----QAPLPYPPPFTNYYQQ------PQQQYAPPSQ 195

Human   414 --------QNKNAPSTAGLGYGS 428
                    |..:..|:|...:||
Yeast   196 QAPVEAQPQQSSGASSAFKSFGS 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	20/53 (38%)
		SH2_Tec_Btk	308..413	CDD:198260	20/112 (18%)
		PTKc_Btk_Bmx	431..686	CDD:173657
		Pkinase_Tyr	436..685	CDD:285015
LSB1	NP_011652.1	SH3	55..108	CDD:214620	19/53 (36%)
LSB1	NP_011652.1	PRK14971	<100..>156	CDD:237874	14/70 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000