DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTK and CDC24

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_009359.1	Gene:	CDC24 / 851190	SGDID:	S000000039	Length:	854	Species:	Saccharomyces cerevisiae

Alignment Length:	632	Identity:	112/632 - (17%)
Similarity:	218/632 - (34%)	Gaps:	183/632 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   100 TVVPEKNPP-----PERQIPRRGEESSEM--EQISIIERF---------------PYPFQV---- 138
            |:.|.|:..     .|.|...:.::||:.  |.:.||:.|               .|..|:
Yeast   247 TIFPSKSKTQQIMNAENQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLEILDKYRQQLLDSN 311

Human   139 VYDEGPLYVFSP----TEELRKRWIHQLK-------------NVIRYNSDLVQKYHPCFWIDGQY 186
            :.....||:..|    ..:.::|::..|:             .:..::....:.|.|  |..||.
Yeast   312 LITSEELYMLFPNLGDAIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEP--WSIGQN 374

Human   187 LCCSQTAKNAMGCQILENR----NGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVST 247
            ......:......::.|::    |..|:..|...|..:.|...|    :|.|.|..| ::...:|
Yeast   375 AAIEFLSSTLHKMRVDESQRFIINNKLELQSFLYKPVQRLCRYP----LLVKELLAE-SSDDNNT 434

Human   248 SELKKVVALYDYMPMNANDLQLRKGDEYFILEE--SNLPWWRAR--DKNGQEGYI------PSNY 302
            .||:..:.:...:..:.|:.| |:.:.:.::::  ..:..|:..  .|.|:..|.      .:|.
Yeast   435 KELEAALDISKNIARSINENQ-RRTENHQVVKKLYGRVVNWKGYRISKFGELLYFDKVFISTTNS 498

Human   303 VTEAEDSIEMYEW------YSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDP 361
            .:|.|...|:|.:      :|:.:|:..|..|:.:             |....:.|:.|.:..|.
Yeast   499 SSEPEREFEVYLFEKIIILFSEVVTKKSASSLILK-------------KKSSTSASISASNITDN 550

Human   362 QGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYH-QHNSAGLISRLKYPVSQQNKNAPSTAGLG 425
            .|         :|...|:  ::|..|:...  |.| ..:||..|.......|..|.|..|::.|
Yeast   551 NG---------SPHHSYH--KRHSNSSSSN--NIHLSSSSAAAIIHSSTNSSDNNSNNSSSSSL- 601

Human   426 YGSWEIDPK-DLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 489
            :.....:|| ||                   ||:..:         |:.::.|.:....:|::.|
Yeast   602 FKLSANEPKLDL-------------------RGRIMI---------MNLNQIIPQNNRSLNITWE 638

Human   490 KLVQLYGVCTKQRPIFII------TEYMANGCLLNYLREM-------RHRFQTQQLLEMCKD--- 538
            .:        |::..|::      |....:.||...:.::       ||...|.......|.
Yeast   639 SI--------KEQGNFLLKFKNEETRDNWSSCLQQLIHDLKNEQFKARHHSSTSTTSSTAKSSSM 695

Human   539 -----VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTS---SVGSKFPV 595
                 ......:..|:| .|..:|:    .:...:.:|||....|......:.|   |:...|
Yeast   696 MSPTTTMNTPNHHNSRQ-THDSMAS----FSSSHMKRVSDVLPKRRTTSSSFESEIKSISENF-- 753

Human   596 RWSPPE--VLMYSKFSSKSD--------------IWAFGVLMWEIYS 626
            :.|.||  :|....:::.|:              :|.|..|:..|.|
Yeast   754 KNSIPESSILFRISYNNNSNNTSSSEIFTLLVEKVWNFDDLIMAINS 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594	18/109 (17%)
		PH_Btk	40..200	CDD:269944	23/142 (16%)
		SH3_BTK	251..305	CDD:212839	8/63 (13%)
		SH2_Tec_Btk	308..413	CDD:198260	20/111 (18%)
		PTKc_Btk_Bmx	431..686	CDD:173657	40/237 (17%)
		Pkinase_Tyr	436..685	CDD:285015	37/231 (16%)
CDC24	NP_009359.1	CDC24	156..242	CDD:399412
		RhoGEF	282..453	CDD:214619	29/177 (16%)
		PH_Scd1	455..667	CDD:270066	49/275 (18%)
		PB1	779..853	CDD:214770	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910