DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTK and btk

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	XP_021336920.1	Gene:	btk / 568653	ZFINID:	ZDB-GENE-070531-1	Length:	640	Species:	Danio rerio

Alignment Length:	657	Identity:	417/657 - (63%)
Similarity:	516/657 - (78%)	Gaps:	25/657 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    35 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVE 99
            ||..:||.:|:|||||||||||||||:|||:||..|:|||:||.|:.:|.|.||.:|:|||.|||
Zfish     1 MADRVLEEVFIKRSQQKKKTSPLNFKERLFVLTHDKISYYDYDAEKAKRKSLKGYVDIEKIRCVE 65

Human   100 TVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKN 164
            .|:||.:.||:|.                     ||||:||||||||||:.::::||.|||:|||
Zfish    66 VVLPEDSAPPDRH---------------------YPFQIVYDEGPLYVFAKSDQIRKHWIHELKN 109

Human   165 VIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSL-KPGSSHRKTKKPLPPTPEE 228
            |:|:|.||:||||||||.||.:.||.|..|.||||::||.:||.: |.||.:|.::|||||||||
Zfish   110 VVRFNKDLMQKYHPCFWEDGVWKCCLQEVKQAMGCRVLETKNGGVFKRGSKNRDSRKPLPPTPEE 174

Human   229 DQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNG 293
            :: ..:||||||...|..:..: .|:|.|:|.||..|||:|||.:||.:||.|:..|::|:||.|
Zfish   175 EK-PARPLPPEPPMPPAFSIGM-TVIAEYEYAPMTTNDLELRKDEEYTLLEISDPNWFKAKDKYG 237

Human   294 QEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKS 357
            :||||||||:.:|.:.:|.|:||.|::.|||||.|||.|.|:|||:||||.| .||||||||.|:
Zfish   238 KEGYIPSNYIVQALNGLEKYDWYCKNINRSQAENLLKTENKDGGFLVRDSGKFTGKYTVSVFTKA 302

Human   358 TGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTA 422
            .|:..|..|||.:..|...|:||||||.|:.|||||||||||:|||:|||||.||.:.:|||.||
Zfish   303 GGETSGSCRHYNILLTADGQFYLAEKHNFTNIPELINYHQHNAAGLVSRLKYIVSNRAQNAPCTA 367

Human   423 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 487
            |||||||||||:.|||::|||.|||||||||||:|::||||||:||||||||:|||||||||.|.
Zfish   368 GLGYGSWEIDPRQLTFIRELGNGQFGVVKYGKWQGRHDVAIKMVKEGSMSEDDFIEEAKVMMKLC 432

Human   488 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFL 552
            |..||||||||||||||:|:|||:|||||||||:|......:..||||||||.|.|:|||:.||:
Zfish   433 HGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEGLLNPTSIALLEMCKDVSEGMKYLEANQFI 497

Human   553 HRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAF 617
            |||||||||||:..|.:||:|||||||||||||||||||||||||||||||:|.|||||||||||
Zfish   498 HRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAF 562

Human   618 GVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILL 682
            ||||||||:.|:|||:|:.|:|..|.|:.|.|||||.:|:|.|:.||.|||||:.||||||:.|:
Zfish   563 GVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHERPDERPTFQELV 627

Human   683 SNILDVM 689
            ..|.|::
Zfish   628 GVIKDLL 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594	70/128 (55%)
		PH_Btk	40..200	CDD:269944	91/159 (57%)
		SH3_BTK	251..305	CDD:212839	30/53 (57%)
		SH2_Tec_Btk	308..413	CDD:198260	66/105 (63%)
		PTKc_Btk_Bmx	431..686	CDD:173657	186/254 (73%)
		Pkinase_Tyr	436..685	CDD:285015	183/248 (74%)
btk	XP_021336920.1	PH_Btk	6..145	CDD:269944	91/159 (57%)
		SH3	195..249	CDD:327375	30/54 (56%)
		SH2	252..357	CDD:326550	65/104 (63%)
		PKc_like	376..630	CDD:328722	186/253 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339759
Domainoid	1	1.000	393	1.000	Domainoid score	I4780
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30953
Inparanoid	1	1.050	873	1.000	Inparanoid score	I2990
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52659
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm27473
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9941
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440