Protein Alignment BTK and slpr

DIOPT Version :10

• Sequence 1: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 122/507 - (24%)
• Similarity: 196/507 - (38%)
• Gaps: 168/507 - (33%)

Human   224 PTPEEDQI-----------LKKPLPPEPAAAPVSTSELKKV----------VALYDYMPMNANDL 267
            |..||.|:           |..|..||     :...:|::|          .|||||.....::|
  Fly     3 PISEEQQLQQQQQQQQLEQLHHPQIPE-----IPIPDLEQVETQVGDGSLWTALYDYDAQGEDEL 62

Human   268 QLRKGDEYFILE-----ESNLPWWRAR--DKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQA 325
            .||:|:...:|.     ..::.||..:  ||   .|..|.::||: ||.:::
  Fly    63 TLRRGEIVVVLSTDSEVSGDVGWWTGKIGDK---VGVFPKDFVTD-EDPLQL------------- 110

Human   326 EQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIP 390
                                    .||   .:.||.|                           |
  Fly   111 ------------------------NVS---SAIGDIQ---------------------------P 121

Human   391 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 455
            ..|.|:                                 |:|.|::     :|:|.|..|..|.:
  Fly   122 HEIEYN---------------------------------ELDIKEV-----IGSGGFCKVHRGYY 148

Human   456 RGQYDVAIKMIKEGSMSE-----DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGC 515
            .|: :||||:..:....:     |..::|||:...|.||.:..|.|||...: :.::.|| |.|.
  Fly   149 DGE-EVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEY-ARGG 210

Human   516 LLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK---QFLHRDLAARNCLVND--------QGVV 569
            .||  |.:..:.....|:.....:...|.||.::   ..:||||.:.|.|:.:        |..:
  Fly   211 SLN--RILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTL 273

Human   570 KVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER 634
            |::||||:|.:.:.:..|:.|:   ..|.||||:..|.:|..||:|::|||:||:.: |:.||:.
  Fly   274 KITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKG 334

Human   635 FTNSETAEHIA-QGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI 685
            |.....|..:| ..|.|..|....|....:|.|||.....:||.||.:|..:
  Fly   335 FDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQL 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	18/70 (26%)
		SH2_Tec_Btk	308..413	CDD:198260	9/104 (9%)
		PTKc_Btk_Bmx	431..686	CDD:173657	83/272 (31%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	17/59 (29%)
		STKc_MLK	134..389	CDD:270963	81/267 (30%)