DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BTK and htl

DIOPT Version :10

Sequence 1:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens
Sequence 2:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster


Alignment Length:684 Identity:152/684 - (22%)
Similarity:262/684 - (38%) Gaps:184/684 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   172 LVQKYHPCFWIDG--QYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKK-PLPPTPEEDQILK 233
            |:..:.|...::|  |.....:..|:.:|.: .:|:..::...::...|.. .|.....:|...|
  Fly    27 LLSIWQPAVQVEGRRQMANSQEMIKDHLGAR-SQNKTPAITNNANQSSTSSADLDDGAADDDDNK 90

Human   234 KPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILE-------ESNLPWWRARDK 291
            ..||...::.|            |...|...:.||.|.......|.       |.|:.|:|....
  Fly    91 ADLPVNVSSKP------------YWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTV 143

Human   292 NGQEGY---------------IP---SNYVTEAEDSI---------------------------- 310
            :...||               :|   .||..:..:|:                            
  Fly   144 DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNL 208

Human   311 --------EMYEWYSKHMTRSQA-----------------------EQL----LKQEGKEGGFIV 340
                    .|:..|...:|..:|                       :||    ::.| :||.:..
  Fly   209 TLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRME-QEGWYTC 272

Human   341 RDSSKAGKYTVSVFAK--------STGDPQGVIRH----YV--------VCSTPQSQYYLAEKHL 385
            .:|:..|:...:.:.:        ..|...|.:..    |:        :..|....:|...|..
  Fly   273 VESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMK 337

Human   386 FSTI--PELINYHQ-------------HNSAGLISRLKYPVSQ---------QNKNAPSTAGLGY 426
            ...:  ..:...||             .:|:|.:..:..||.:         ||.|.|:... .|
  Fly   338 HEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN-EY 401

Human   427 -----GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSED--EFIEEAKVMM 484
                 .:||:....|.....||.|.||.|...:..... ||:||:|||...:|  ..:.|.:||.
  Fly   402 EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMK 465

Human   485 NLS-HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-------------------HRFQT 529
            .:. |..::.|.|.|::..|:::|.||..:|.|.::|.:.|                   |....
  Fly   466 IIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITE 530

Human   530 QQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLD-DEYTSSVGSKF 593
            :.|::....:...|:||.|::.:||||||||.||:|..|:|::||||:|.:.. |.|..:...:.
  Fly   531 KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL 595

Human   594 PVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETA-EHIAQGLRLYRPHLAS 657
            |::|..||.|....:.||||:|::|:|:|||.:.|:.||....::|.. .::..|.|:.:|...|
  Fly   596 PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660

Human   658 EKVYTIMYSCWHEKADERPTFKILLSNILDVMDE 691
            ..:|.:|..|||..||:||.|    :.|::.||:
  Fly   661 MNIYILMRQCWHFNADDRPPF----TEIVEYMDK 690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BTKNP_001274273.1 PH_Btk 40..200 CDD:269944 6/29 (21%)
SH3_BTK 251..305 CDD:212839 15/78 (19%)
SH2_Tec_Btk 308..413 CDD:198260 24/202 (12%)
PTKc_Btk_Bmx 431..686 CDD:173657 89/278 (32%)
htlNP_524394.2 Ig 101..191 CDD:472250 17/101 (17%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 11/89 (12%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 0/4 (0%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 94/292 (32%)

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