DRSC/TRiP Functional Genomics Resources

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Protein Alignment BTK and Csk

DIOPT Version :10

Sequence 1:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens
Sequence 2:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster


Alignment Length:400 Identity:134/400 - (33%)
Similarity:223/400 - (55%) Gaps:33/400 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   299 PSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGDPQ 362
            |....:..|..:....|:...:||.:||.|| |..::|.|:||:|:. .|.||:.|..:|.    
  Fly   668 PQQGRSRCEVKLNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDYTLCVCFQSK---- 727

Human   363 GVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNK-----NAPSTA 422
              :.||.| ...:::..:.::..|..:.:|:.:::.::.||.::|...:.:..|     |:....
  Fly   728 --VEHYRV-KYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 789

Human   423 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK-EGSMSEDEFIEEAKVMMNL 486
            ..|   |.|...:|...:.:|.|:||.|..|..|.: .||:||:| ||::  .:|:.||.||..|
  Fly   790 DKG---WVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTL 848

Human   487 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLRE--MRHRFQTQQLLEMCKDVCEAMEYLESK 549
            .|:.||:..|:....:.::::||||:.|.|::|||.  .:|..:..|:: ...|....|||||:|
  Fly   849 EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII-FAYDTASGMEYLEAK 912

Human   550 QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDI 614
            :.:||||||||.|:::..|.|||||||:|   ::.|...|| |.|::|:.||.|...:||:|||:
  Fly   913 KVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDM 973

Human   615 WAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTF- 678
            |:||:|:|||||.|::||.|...::..:|:..|.::..|.....::|.:|...|.....:|||| 
  Fly   974 WSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFA 1038

Human   679 ----KILLSN 684
                |:.|.|
  Fly  1039 ELKVKLQLLN 1048

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BTKNP_001274273.1 PH_Btk 40..200 CDD:269944
SH3_BTK 251..305 CDD:212839 1/5 (20%)
SH2_Tec_Btk 308..413 CDD:198260 26/105 (25%)
PTKc_Btk_Bmx 431..686 CDD:173657 101/261 (39%)
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 26/104 (25%)
PTKc_Csk_like 793..1047 CDD:270635 101/261 (39%)
Blue background indicates that the domain is not in the aligned region.

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