DRSC/TRiP Functional Genomics Resources

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Protein Alignment BTK and Fak

DIOPT Version :10

Sequence 1:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens
Sequence 2:NP_001137718.1 Gene:Fak / 37233 FlyBaseID:FBgn0020440 Length:1500 Species:Drosophila melanogaster


Alignment Length:579 Identity:143/579 - (24%)
Similarity:234/579 - (40%) Gaps:154/579 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   228 EDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKN 292
            |.:|..|...|:...|......|||::.:......|.||::..  ..:|.|              
  Fly   207 EKEIGFKSFLPQSVIATSKPKNLKKLIQVGYKKVYNYNDIEYL--TRFFDL-------------- 255

Human   293 GQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQL--LKQEGKEGGFIVRDSSKAGKYTVSVFA 355
                 :.:.|:|.       :|.:|  :|.|.|..:  :...|...|...:...:|....|:.|.
  Fly   256 -----LKNIYLTN-------FEQFS--VTLSSAWNISGILHVGPHIGISYQTHPQASLKNVAQFK 306

Human   356 KSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQH---------------------- 398
            .        :.....|:.|:.:  |::....:|.|||.|::.:                      
  Fly   307 D--------VVSIKTCTLPKEK--LSKSGENTTEPELQNFNCNCQKIKTQIKISASNNVEDLVIT 361

Human   399 ----NSA-----------GLISR-LKYPVSQQNKNA---------PSTAGLGYG----------- 427
                |:|           .|:|: |::.:..:..||         |:.|.||..           
  Fly   362 CNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGSNKSTSSQGKPML 426

Human   428 ----------------------SWEIDPKDLTFLKELGTGQFGVV--------KYGKWRG----- 457
                                  ::|:|...:|...::|.||||.|        |.||.:.     
  Fly   427 TDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNG 491

Human   458 ---------------QYDVAIKMIKEGSMSE--DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIF 505
                           ...||||..|.....|  :.|:.||.:|....|..:::|.|:|:.. ||:
  Fly   492 KNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICSVM-PIW 555

Human   506 IITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVK 570
            |:.|....|.|..||:....|.....||:.|..:..|:.|||||:|:|||:||||.||:....||
  Fly   556 IVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVK 620

Human   571 VSDFGLSRYVLDDEYTSSVGS-KFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER 634
            ::||||||:|.|..|..|..: ..|::|..||.:.:.:|::.||:|.|||.:|||..||..|::.
  Fly   621 LADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQG 685

Human   635 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 693
            ..||:....:..|.||..|.....::|::|..||..:..:||.||.:...:.:::.|:|
  Fly   686 VKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDS 744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BTKNP_001274273.1 PH_Btk 40..200 CDD:269944
SH3_BTK 251..305 CDD:212839 8/53 (15%)
SH2_Tec_Btk 308..413 CDD:198260 23/144 (16%)
PTKc_Btk_Bmx 431..686 CDD:173657 96/285 (34%)
FakNP_001137718.1 B41 24..267 CDD:214604 16/87 (18%)
FERM_B-lobe 152..257 CDD:271216 13/70 (19%)
FERM_C_FAK1 263..394 CDD:270011 23/149 (15%)
PTKc_FAK 450..744 CDD:133187 98/294 (33%)
Focal_AT 1250..1376 CDD:460992
Blue background indicates that the domain is not in the aligned region.

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