Protein Alignment BTK and Btk

DIOPT Version :9

• Sequence 1: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_001007799.2
• Gene: Btk / 367901
• RGDID: 1359683
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 661
• Identity: 649/661 - (98%)
• Similarity: 658/661 - (99%)
• Gaps: 2/661 - (0%)

Human    35 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVE 99
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVE 65

Human   100 TVVPEKNPPPERQI--PRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQL 162
            ||||||||||||||  |||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 TVVPEKNPPPERQIPVPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQL 130

Human   163 KNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPE 227
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 KNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPE 195

Human   228 EDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKN 292
            |||||||||||||.|||:|||||||||||||||||||||||||||:|||||||||||||||||||
  Rat   196 EDQILKKPLPPEPTAAPISTSELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKN 260

Human   293 GQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKS 357
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 GQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKS 325

Human   358 TGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTA 422
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat   326 TGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTA 390

Human   423 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 487
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
  Rat   391 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLS 455

Human   488 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFL 552
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFL 520

Human   553 HRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAF 617
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 HRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAF 585

Human   618 GVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILL 682
            ||||||||||||:|||||||||||||||||||||||||||::|||||||||||||||||:|||||
  Rat   586 GVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADERPSFKILL 650

Human   683 SNILDVMDEES 693
            |||||||||||
  Rat   651 SNILDVMDEES 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594	128/130 (98%)
		PH_Btk	40..200	CDD:269944	159/161 (99%)
		SH3_BTK	251..305	CDD:212839	52/53 (98%)
		SH2_Tec_Btk	308..413	CDD:198260	103/104 (99%)
		PTKc_Btk_Bmx	431..686	CDD:173657	249/254 (98%)
		Pkinase_Tyr	436..685	CDD:285015	243/248 (98%)
Btk	NP_001007799.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691967
Domainoid	1	1.000	479	1.000	Domainoid score	I7953
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30953
Inparanoid	1	1.050	1259	1.000	Inparanoid score	I3753
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52659
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto135840
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.410