Protein Alignment BTK and Src42A

DIOPT Version :10

• Sequence 1: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 211/687 - (30%)
• Similarity: 328/687 - (47%)
• Gaps: 104/687 - (15%)

Human    21 SGGEHTGELQKEEAMAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGS 85
            |...::||.|:|....    |....||:|.|::....|     .||.:.....|.....:.|...
  Fly   977 SYSRNSGEDQQETTGK----EETKPKRTQAKRRIGVTN-----LLLPLDSEELYTRIIAQQRGLD 1032

Human    86 KKGSIDVEKITCVETVVPEKNPPPERQIPRRG--EESSEMEQISI-IERFPYPFQVVYDEGPLYV 147
            |:.|.:           ||:....|.|:..|.  .:||.::.||: :...|             .
  Fly  1033 KEHSQE-----------PEEKCASEEQMCTRNALTKSSSLDAISLSVAISP-------------A 1073

Human   148 FSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILEN-RNGSLKP 211
            .||:....:|.:.|.:.:.::....:.|.|.   :|.    |.|...:....|.|.. .|.:...
  Fly  1074 SSPSPPRPRRSLKQHRCLQQHQQTPLAKKHS---LDN----CLQVVSSTTSRQPLRRWSNQTPLK 1131

Human   212 GSSHRKTKKPLPPTP-EEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDL------QL 269
            .:.|..|:: ||.|. |:.:.|       |||...|.|.....:::.|..|......      ..
  Fly  1132 CTCHPATEE-LPLTAIEKSRSL-------PAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTA 1188

Human   270 RKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEG 333
            :||....:.|                 :....::.|.       .||.:.:.|.:|| :||..|.
  Fly  1189 KKGKSRRLSE-----------------FTRGEFLNEK-------SWYFRKIKRIEAEKKLLLPEN 1229

Human   334 KEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQ 397
            :.|.|::||| |:...|::||   ..||   .::||.:....:..:::|.:..|.|:.||:.::.
  Fly  1230 EHGAFLIRDSESRHNDYSLSV---RDGD---TVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS 1288

Human   398 HNSAGLISRLKYPVSQQNK-------NAPSTAGLGY---GSWEIDPKDLTFLKELGTGQFGVVKY 452
            .:|.||...|..|..|.|.       ..|.|.||.:   ..||||...|.|:::||:||||.|..
  Fly  1289 KDSDGLCVNLCKPCVQTNSFSGVFEIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWE 1353

Human   453 GKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL 517
            |.|.....||||.:|.|:|...:|:.||::|..|.|.||:|||.|||.:.||:||||.|.:|.||
  Fly  1354 GLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLL 1418

Human   518 NYLREMRHR---FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY 579
            .||:.:..:   .:.|.|::|...:...|.||||:.::||||||||.||.|..:||::||||:|.
  Fly  1419 EYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARL 1483

Human   580 VLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHI 644
            :.:|||.:.||::||::|:.||...|||||.|||:|:||:|:.|:.:.|::||...||:|....:
  Fly  1484 IKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQV 1548

Human   645 AQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKIL 681
            ..|.|:.:|.....::|.||..|||:....||||:.|
  Fly  1549 EHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 1585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH_Btk	40..200	CDD:269944	31/162 (19%)
		SH3_BTK	251..305	CDD:212839	5/59 (8%)
		SH2_Tec_Btk	308..413	CDD:198260	31/106 (29%)
		PTKc_Btk_Bmx	431..686	CDD:173657	115/254 (45%)
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	30/96 (31%)
		PTKc_Frk_like	1328..1596	CDD:270653	117/258 (45%)