DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTK and Btk29A

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	302/773 - (39%)
Similarity:	411/773 - (53%)	Gaps:	152/773 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    33 EAMAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITC 97
            |.:..|:.....:||:|.||:.:|:|:|.|.|.||....||  :|.|...|..::|.|.::.:..
  Fly    37 ERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSY--FDVENVERRRERGRIHLKGVRL 99

Human    98 VE--TVVPEKNPP--PERQIPRRGEESSEMEQISIIERFPYPFQVVYDE---------------- 142
            ||  ||..|...|  |:                      .|||||.|.|
  Fly   100 VEEATVSGEGGDPFAPD----------------------GYPFQVGYCEISASANSHQLENGNGG 142

Human   143 -----------------GPLYVFSPTEELRKRWIHQLKNVIR-YNSDLVQKYHPCFWIDGQYLCC 189
                             ..|||.:.:|:.|..||..::.|.. .|:....:|||..|...::.||
  Fly   143 GSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCC 207

Human   190 SQTAKNAMGCQI-----------------LENRNGSLKPGSSHRKTKKPL--------------- 222
            ...::...||:.                 .:|...|:.|.||...::..|
  Fly   208 KGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGG 272

Human   223 -------------------PPTPEEDQ------------------ILKKPLP---PEPAAAPVST 247
                               .||..:.|                  :|...:|   |.| ..|.|.
  Fly   273 LGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTP-GTPNSK 336

Human   248 SE-----LKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYV-TEA 306
            ::     :|.|||||.:..:...||.|.|..||.::::|...||:.:|..|..|||||||| .:|
  Fly   337 AKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKA 401

Human   307 EDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVC 371
            ...:|.||||...|:|.:||.||||..|||.|:||.||..|.||:|:..|.   ||..::||.:.
  Fly   402 LLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKV---PQSHVKHYHIK 463

Human   372 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDL 436
            ...:.:|||:|||...|||:|||||:|||.||..|||  .|..::..|.||||.:..|||.|.:|
  Fly   464 QNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLK--SSPCDRPVPPTAGLSHDKWEIHPMEL 526

Human   437 TFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ 501
            ..::|||:||||||:.|||||..|.|:||:|||:||||:||||||||..|.|..||||||||:|.
  Fly   527 MLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKH 591

Human   502 RPIFIITEYMANGCLLNYLREMRHR----FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCL 562
            |||:|:||||.:|.||||||  ||.    .....||:||..|.:.|.|||...::||||||||||
  Fly   592 RPIYIVTEYMKHGSLLNYLR--RHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCL 654

Human   563 VNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 627
            |..:.||||:||||:||||||:||||.|:|||::|:|||||.|::||||||:||:|||||||::.
  Fly   655 VGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTC 719

Human   628 GKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI 685
            |||||.|..|:|..|.:.:|:.|.:|...::::|.:|..||....:|||.|::|:..:
  Fly   720 GKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594	42/165 (25%)
		PH_Btk	40..200	CDD:269944	49/197 (25%)
		SH3_BTK	251..305	CDD:212839	25/54 (46%)
		SH2_Tec_Btk	308..413	CDD:198260	52/104 (50%)
		PTKc_Btk_Bmx	431..686	CDD:173657	149/259 (58%)
		Pkinase_Tyr	436..685	CDD:285015	147/252 (58%)
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	50/201 (25%)
		SH3_Tec_like	346..399	CDD:212702	24/52 (46%)
		SH2_Tec_family	403..505	CDD:198188	53/106 (50%)
		PTKc_Tec_like	521..778	CDD:173637	149/259 (58%)
		Pkinase_Tyr	526..777	CDD:285015	147/252 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1267
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1050
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42091
orthoMCL	1	0.900	-	-		OOG6_102306
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830