DRSC/TRiP Functional Genomics Resources

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Protein Alignment BTK and dock

DIOPT Version :10

Sequence 1:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens
Sequence 2:NP_722657.1 Gene:dock / 33262 FlyBaseID:FBgn0010583 Length:548 Species:Drosophila melanogaster


Alignment Length:375 Identity:73/375 - (19%)
Similarity:118/375 - (31%) Gaps:168/375 - (44%)


- Green bases have known domain annotations that are detailed below.


Human   156 KRW--IHQLKNVIRY-NSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRK 217
            |.|  :...:|...| .|:.|:|..|                     .:.::....:|.||..:.
  Fly   184 KHWWRVQNSRNQSGYVPSNYVKKEKP---------------------SLFDSIKKKVKKGSGSKT 227

Human   218 TKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESN 282
            .....|....|...:.:.|||:||.| :.|:.:|     |:|.....::|.|.||....|||:||
  Fly   228 LPNCSPSRQVESPTMSRRLPPDPAEA-IGTAVVK-----YNYQAQQPDELSLTKGTRILILEKSN 286

Human   283 LPWWR------------------------------------------------------------ 287
            ..|||                                                            
  Fly   287 DGWWRGQSGNSVGWFPSNYTTEDCDNDGEIHTYAMAENVLDIVVALYSFTSNNDQELSFEKGDRL 351

Human   288 --------------ARDKNGQEGYIPSNYVTE--------------------------------A 306
                          ||:..||.|.:|.||:.|                                .
  Fly   352 EIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGG 416

Human   307 EDSIEM-----------------------YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAG 347
            .||:|.                       ..||...:||||.:.:|...|.:|.|::||| :..|
  Fly   417 NDSMERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMG 481

Human   348 KYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQ 397
            .|:||:.|      .|..:|:.| ...|:.|.:.::. |.::.:|::::|
  Fly   482 DYSVSLKA------PGRNKHFRV-HVEQNMYCIGQRK-FHSLDQLVDHYQ 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BTKNP_001274273.1 PH_Btk 40..200 CDD:269944 8/46 (17%)
SH3_BTK 251..305 CDD:212839 23/127 (18%)
SH2_Tec_Btk 308..413 CDD:198260 29/114 (25%)
PTKc_Btk_Bmx 431..686 CDD:173657
dockNP_722657.1 SH3_Nck_1 154..204 CDD:212699 5/19 (26%)
SH3_Nck_2 256..308 CDD:212700 16/56 (29%)
SH3_Nck_3 328..383 CDD:212701 8/54 (15%)
SH2_Nck_family 446..538 CDD:198196 26/86 (30%)
Blue background indicates that the domain is not in the aligned region.

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