Protein Alignment BTK and sev

DIOPT Version :10

• Sequence 1: NP_001274273.1
• Gene: BTK / 695
• HGNCID: 1133
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_511114.2
• Gene: sev / 32039
• FlyBaseID: FBgn0003366
• Length: 2554
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 186/710 - (26%)
• Similarity: 280/710 - (39%)
• Gaps: 179/710 - (25%)

Human    60 KKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEME 124
            ::||.....|:|:           |.|.||  ...:.......|.|:...||...|   ..:|:.
  Fly  1855 ERRLETAGTHRLT-----------GIKPGS--GYSLWVQAHATPTKSNSSERLHVR---SFAELP 1903

Human   125 QISIIERFPYPFQVVYDEGP-------LYVFSPTEELR--------KRWIHQLKNVIRYNSDLVQ 174
            ::.::|..||...:.:...|       |...|..|:||        |..:..|:...||...|:.
  Fly  1904 ELQLLELGPYSLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLL 1968

Human   175 KY-----HPCF-----------------------WIDGQYLCCSQTAKNAMGCQILENRNGSLKP 211
            .|     .|.:                       .|..:....:.||....|..|......:|:.
  Fly  1969 GYAATPGAPLYHGTAEVYETLGDAPSQPGKPQLEHIAEEVFRVTWTAARGNGAPIALYNLEALQA 2033

Human   212 GSSHRKTKK-----------PLP----PTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMP 261
            .|..|:.::           .||    |...|||.|..          .:|:||..:|.
  Fly  2034 RSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDF----------CNTTELSCIVK------ 2082

Human   262 MNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE 326
                           .|..|.|..:|.|.::.:.|:.|                ||:...| .||
  Fly  2083 ---------------SLHSSRLLLFRVRARSLEHGWGP----------------YSEESER-VAE 2115

Human   327 QLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPE 391
            ..:..| |.|..::...:.|...:..|.|            .|:....|.:...|:|.|
  Fly  2116 PFVSPE-KRGSLVLAIIAPAAIVSSCVLA------------LVLVRKVQKRRLRAKKLL------ 2161

Human   392 LINYHQHNSAGLISRLKYPVSQQN----KNAPSTAGLGYGSWEIDPK----DLTFLKELGTGQFG 448
                 |.:...:.|.|....:||.    :|...:..|......:.|:    .|..|:.||:|.||
  Fly  2162 -----QQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDADIALLPQINWSQLKLLRFLGSGAFG 2221

Human   449 VVKYGKWRGQ-----YDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIIT 508
            .|..|:.:.:     ..||||.:::|:....|.::||::|.|..||.:|.|.|:|.....|.:|.
  Fly  2222 EVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIM 2286

Human   509 EYMANGCLLNYLREMRHRFQTQ-----------QLLEMCKDVCEAMEYLESKQFLHRDLAARNCL 562
            |:|..|.||:|||..| ...||           :||.||.||.....|||...|:|||||.||||
  Fly  2287 EHMEAGDLLSYLRAAR-ATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCL 2350

Human   563 VND-------QGVVKVSDFGLSRYVLDDEYTSSVG-SKFPVRWSPPEVLMYSKFSSKSDIWAFGV 619
            |.:       :..||:.||||:|.:...:|....| ...||||..||.|:...|:::||:|||||
  Fly  2351 VTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGV 2415

Human   620 LMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFK 679
            |.|||.:||:.||....|.|...|:.:|.||.:|.:.:||:|:::..||.....|||:|:
  Fly  2416 LCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFR 2475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH_Btk	40..200	CDD:269944	34/182 (19%)
		SH3_BTK	251..305	CDD:212839	8/53 (15%)
		SH2_Tec_Btk	308..413	CDD:198260	19/104 (18%)
		PTKc_Btk_Bmx	431..686	CDD:173657	107/277 (39%)
sev	NP_511114.2	fn3	439..520	CDD:394996
		FN3	826..921	CDD:238020
		Vgb	992..>1118	CDD:443399
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		fn3	1800..1891	CDD:394996	10/48 (21%)
		FN3	1993..2111	CDD:238020	28/164 (17%)
		PTKc_c-ros	2213..2483	CDD:270640	104/264 (39%)