DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTK and hse1

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_595425.1	Gene:	hse1 / 2540055	PomBaseID:	SPBC1734.08	Length:	373	Species:	Schizosaccharomyces pombe

Alignment Length:	212	Identity:	56/212 - (26%)
Similarity:	85/212 - (40%)	Gaps:	36/212 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   208 SLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEP---AAAPVSTSELKKVVALYDYMPMNANDLQL 269
            :|....|..::.|...|...:|:.|:|....:.   |.:|.||  :.:|.||||:......:|..
pombe   174 ALSLSESTAQSNKVENPQSTKDEPLQKTNQRQESNLATSPAST--VSRVRALYDFAATEQGELSF 236

Human   270 RKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTE-AEDSIEMYEWYSKHMTRS------QAEQ 327
            :|||...:||.....||:...||. .|..|.|||.. .|.:||. :..|.||.:.      |.::
pombe   237 KKGDIILVLESVYKDWWKGSCKNA-VGIFPVNYVQRVVEPTIEQ-QRQSAHMEQQVFDALPQIDE 299

Human   328 LLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPEL 392
            ||............|.:..|||                 |.::...|: ...|.||:. |...||
pombe   300 LLDTLSTTSPDAADDDALQGKY-----------------HAMIALRPK-LVRLIEKYA-SQKEEL 345

Human   393 INYHQHNSAGLISRLKY 409
            ::.   |...|::|..|
pombe   346 MDL---NERLLVARRDY 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	20/53 (38%)
		SH2_Tec_Btk	308..413	CDD:198260	24/108 (22%)
		PTKc_Btk_Bmx	431..686	CDD:173657
		Pkinase_Tyr	436..685	CDD:285015
hse1	NP_595425.1	VHS	9..140	CDD:197630
		SH3_GRB2_like_C	219..271	CDD:212739	20/52 (38%)
		GAT	297..362	CDD:281166	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910