DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTK and src-2

DIOPT Version :9

Sequence 1:	NP_001274273.1	Gene:	BTK / 695	HGNCID:	1133	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_493502.1	Gene:	src-2 / 173296	WormBaseID:	WBGene00005078	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	178/502 - (35%)
Similarity:	276/502 - (54%)	Gaps:	35/502 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   211 PGSS---HRKT---KKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKK---------VVALYDYM 260
            ||::   |..:   ::.||..|....|       .|.||..|.:.:.|         .|||:.|.
Worm    12 PGATSPVHTSSTLGRESLPSHPRIPSI-------GPIAASSSGNTIDKNQNISQSANFVALFQYD 69

Human   261 PMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQ 324
            ....:||..:|.|...||.::...||.||.| .|:.||||||||.. |.|||...||...|.|..
Worm    70 ARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNYVAR-EKSIESQPWYFGKMRRID 133

Human   325 AEQ-LLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFST 388
            ||: ||....:.|.|:||| |::.::.:|:..:....    ::||.:.......|::|.:..|:|
Worm   134 AEKCLLHTLNEHGAFLVRD-SESRQHDLSLSVRENDS----VKHYRIRQLDHGGYFIARRRPFAT 193

Human   389 IPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGY-GSWEIDPKDLTFLKELGTGQFGVVKY 452
            :.:||.::|..:.||...|..|.::  ..||.|....| ..||:|.:.:..::::|.||||.|..
Worm   194 LHDLIAHYQREADGLCVNLGAPCAK--SEAPQTTTFTYDDQWEVDRRSVRLIRQIGAGQFGEVWE 256

Human   453 GKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL 517
            |:|.....||:|.:|.|:....:|:.||::|..|.|.||:.||.|||:..||.|:||.|... ||
Worm   257 GRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQEN-LL 320

Human   518 NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVL- 581
            .:|:....:.|..||:|:...|...|.|||...|:||||||||.|:|:...||::||||:|.::
Worm   321 TFLQRRGRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMK 385

Human   582 DDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQ 646
            ::||.:..|::||::|:.||...|::|::|||:|:||:|:.||.:.|::||...||:|..:.:..
Worm   386 ENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDA 450

Human   647 GLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 693
            |.|:..|......:|.||..||....|:||||:.|...:.|:.:.:|
Worm   451 GYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLFNLDS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTK	NP_001274273.1	PH	38..167	CDD:278594
		PH_Btk	40..200	CDD:269944
		SH3_BTK	251..305	CDD:212839	25/63 (40%)
		SH2_Tec_Btk	308..413	CDD:198260	31/105 (30%)
		PTKc_Btk_Bmx	431..686	CDD:173657	102/255 (40%)
		Pkinase_Tyr	436..685	CDD:285015	101/249 (41%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	21/50 (42%)
		SH2_Src_Src42	120..215	CDD:198233	28/99 (28%)
		PTKc_Frk_like	231..496	CDD:270653	105/265 (40%)
		Pkinase_Tyr	240..489	CDD:285015	101/249 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810