| Sequence 1: | NP_001274273.1 | Gene: | BTK / 695 | HGNCID: | 1133 | Length: | 693 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_038510.2 | Gene: | Btk / 12229 | MGIID: | 88216 | Length: | 659 | Species: | Mus musculus |
| Alignment Length: | 659 | Identity: | 648/659 - (98%) |
|---|---|---|---|
| Similarity: | 658/659 - (99%) | Gaps: | 0/659 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 35 MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVE 99
Human 100 TVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKN 164
Human 165 VIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEED 229
Human 230 QILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQ 294
Human 295 EGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG 359
Human 360 DPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGL 424
Human 425 GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 489
Human 490 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 554
Human 555 DLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGV 619
Human 620 LMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSN 684
Human 685 ILDVMDEES 693 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| BTK | NP_001274273.1 | PH | 38..167 | CDD:278594 | 127/128 (99%) |
| PH_Btk | 40..200 | CDD:269944 | 158/159 (99%) | ||
| SH3_BTK | 251..305 | CDD:212839 | 51/53 (96%) | ||
| SH2_Tec_Btk | 308..413 | CDD:198260 | 103/104 (99%) | ||
| PTKc_Btk_Bmx | 431..686 | CDD:173657 | 251/254 (99%) | ||
| Pkinase_Tyr | 436..685 | CDD:285015 | 245/248 (99%) | ||
| Btk | NP_038510.2 | PH_Btk | 6..166 | CDD:269944 | 158/159 (99%) |
| Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250 | 12..24 | 11/11 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 171..210 | 37/38 (97%) | |||
| SH3_BTK | 217..271 | CDD:212839 | 51/53 (96%) | ||
| SH2_Tec_Btk | 274..378 | CDD:198260 | 102/103 (99%) | ||
| PTKc_Btk_Bmx | 397..652 | CDD:173657 | 251/254 (99%) | ||
| Inhibitor-binding. /evidence=ECO:0000250 | 474..479 | 4/4 (100%) | |||
| CAV1-binding. /evidence=ECO:0000250 | 581..588 | 6/6 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83968604 | |
| Domainoid | 1 | 1.000 | 509 | 1.000 | Domainoid score | I7371 |
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0197 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H30953 | |
| Inparanoid | 1 | 1.050 | 1340 | 1.000 | Inparanoid score | I3666 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG52659 | |
| OrthoDB | 1 | 1.010 | - | - | D1047190at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000006 | |
| OrthoInspector | 1 | 1.000 | - | - | oto119540 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_102306 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24418 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R9941 |
| SonicParanoid | 1 | 1.000 | - | - | X592 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 18 | 18.300 | |||||