Protein Alignment ZNF354A and Meics

DIOPT Version :10

• Sequence 1: NP_005640.2
• Gene: ZNF354A / 6940
• HGNCID: 11628
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_524062.1
• Gene: Meics / 39539
• FlyBaseID: FBgn0025874
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 154/530 - (29%)
• Similarity: 238/530 - (44%)
• Gaps: 104/530 - (19%)

Human    91 HKTTKSTQTQDSSFQGLILKRSNRNVPWDLKLEKPYIYEGRLEKKQDKKGS------FQIVSATH 149
            ||..:|.|......|   |.:||.|                |.:...::|:      |:||....
  Fly    83 HKCEQSFQFFSQLLQ---LDKSNSN----------------LSRSHCRRGTMNPLIPFEIVGCED 128

Human   150 KKIPTIERSHKN-----TELSQNFSPKSVLIRQQILPREKTPPKCEIQGNSLKQNSQLLNQPKIT 209
            .....:.:...|     |::.:....|:. ..|:..|.::.   .||..|.:|...::..|
  Fly   129 PLDTNVTKLDANRPDVKTDIDEPTDGKAT-NGQESEPLQEV---FEITMNDIKTEDEVSIQ---- 185

Human   210 ADKRYKCSLCEKTFINTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYICKE 274
                       :||.:.........|...|     :|.|..::..|       |...::|:|...
  Fly   186 -----------ETFEDAFDEENDNNNTDSE-----REDSDQWTVGS-------TEDQDEPWIPGG 227

Human   275 CGKAFTLSTSLYKHLRTHTV---EKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPGRKASS 336
            .|:              .||   .:|..|.|||.|:|.:..|..|...|.|:.
  Fly   228 GGR--------------QTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQG------------ 266

Human   337 CSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHE 401
                        ..:|.:||:.||..|::::.|..|:|.||||:||||..|.:|::...:|..|.
  Fly   267 ------------DTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHM 319

Human   402 RIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPC 466
            ..|..||.::|.:|.|.|.:...|..|...||||:.|.|.:|.:..:.:|.|.:|.|:|..|:|.
  Fly   320 HTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPF 384

Human   467 KCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISF 531
            ||::|||.|.|:..||.|.|:|.|:|.:||.:|.|:|...|::..|||.|:|.||::|||||.:|
  Fly   385 KCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAF 449

Human   532 GQSSALIQHRRIHTGEKPFKCNTCGKTFRQSSSRIAHQRIH--TGEKPYECNTCGKLFNHRSSLT 594
            ..:..|..|.||||||||:||:.|||.|..:.|.:.|...|  ..::|::|:.|.|.::.:.||.
  Fly   450 SHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLR 514

Human   595 NHYKIHIEED 604
            .|.|.|...|
  Fly   515 GHEKTHKNPD 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF354A	NP_005640.2	KRAB	14..73	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..106		4/14 (29%)
		C2H2 Zn finger	189..208	CDD:275368	5/18 (28%)
		COG5048	198..600	CDD:227381	129/406 (32%)
		C2H2 Zn finger	216..236	CDD:275368	2/19 (11%)
		C2H2 Zn finger	244..264	CDD:275368	3/19 (16%)
		C2H2 Zn finger	272..292	CDD:275368	1/19 (5%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	10/19 (53%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
Meics	NP_524062.1	zf-AD	20..95	CDD:462262	4/11 (36%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		SFP1	<296..374	CDD:227516	28/77 (36%)
		COG5048	<299..486	CDD:227381	81/186 (44%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		COG5048	<395..583	CDD:227381	56/130 (43%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370