DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TCF12 and sage

DIOPT Version :9

Sequence 1:	XP_011520261.1	Gene:	TCF12 / 6938	HGNCID:	11623	Length:	718	Species:	Homo sapiens
Sequence 2:	NP_524287.1	Gene:	sage / 41105	FlyBaseID:	FBgn0037672	Length:	268	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	53/232 - (22%)
Similarity:	95/232 - (40%)	Gaps:	55/232 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   472 LGPSHNAPIGSLNSNY----GGSSLVA------SSRSASMVGTHREDSVS---LNGNHSVLSSTV 523
            ||...::...:::.||    .|:.|:|      .|.|.|::|.:.:::.:   |...:||:...|
  Fly    51 LGAPQSSSCPAVSLNYTLTADGAGLLAYAPTHPHSYSPSVMGGYEKEAHNMGLLPPTYSVIPQPV 115

Human   524 TTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVS 588
            :.            :..| |..:|:.|..|.     .|...|..||               :.:|
  Fly   116 SM------------WHAG-QVATGSPVGLEC-----NKPSELVPPP---------------MYMS 147

Human   589 SRGRTSSTNEDEDL----NP---EQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKS 646
            ..|.:.:.:.:.|:    ||   |:.::.||:.|.....|||.|:||:|.||..|.....:...:
  Fly   148 YSGGSIANSTEVDIAKEHNPAWREKALQMEKDYRRTACDRERTRMRDMNRAFDLLRSKLPISKPN 212

Human   647 EKPQTKLLILHQAVAVILSLEQQVRERNL--NPKAAC 681
            .|..:|:..|..|:..|..|:..:||.::  |....|
  Fly   213 GKKYSKIESLRIAINYINHLQAMLRESSVGQNGNGCC 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TCF12	XP_011520261.1	CytochromB561_N	287..>460	CDD:286826
TCF12	XP_011520261.1	HLH	619..672	CDD:197674	16/52 (31%)
sage	NP_524287.1	HLH	181..233	CDD:278439	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910