DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TCF12 and da

DIOPT Version :9

Sequence 1:	XP_011520261.1	Gene:	TCF12 / 6938	HGNCID:	11623	Length:	718	Species:	Homo sapiens
Sequence 2:	NP_001356956.1	Gene:	da / 34413	FlyBaseID:	FBgn0267821	Length:	775	Species:	Drosophila melanogaster

Alignment Length:	733	Identity:	234/733 - (31%)
Similarity:	323/733 - (44%)	Gaps:	191/733 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    77 QPSPSYDSSR---GFTDSPHYSDHLNDSRLGAHEGLSPTPFMNSNLMGKTSERGS---------- 128
            ||:.:..:.|   |...||:.|       ||...|:.|:.|   |.|..|...|:
  Fly    26 QPTGTVGADRGGGGGYHSPYGS-------LGVENGMYPSDF---NSMHDTVNGGNNRYANASTVD 80

Human   129 --FSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPLHDSAAL---- 187
              |...:..:|...||..:...:..:|..|..:|....|      .:...:::.:|.:..|
  Fly    81 QYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSG------HSIDQQQQQVHQADGLGMGG 139

Human   188 --------DPLQAKKVRKVPP---GLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQD 241
                    |.:.......:||   ..|:|.....|.:   .:::|...:..|| ::|.|.   |.
  Fly   140 GGGGGVGADGMHCPVTTGLPPISSFRPTSGGIGGPGA---GQQAPVNVNVNPP-AVFNSP---QA 197

Human   242 GTHNSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPM 306
            ..||.                    |..:..|..|:.|.| .|..|::.||:.|.|     ||..
  Fly   198 HNHNH--------------------TVQAQHSALSTAGPL-GHHSLNHTPHAHSHT-----LPLP 236

Human   307 SSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKAL-ASIYSP-DHTSSSFP 369
            .:...|.|...|:.:..::|.:..||:..|. |.:...:..|::...|| ..:|.| |.:.|||.
  Fly   237 HALPHGHTLPHPHHSQQNSPAVQSSDAFSGA-GASVKVAGAGNSSAAALRQQMYMPADQSISSFG 300

Human   370 SNPSTPVGSPSPLT-------------GTSQWPRP---GGQAPSSPSYE------NSLHSLKNRV 412
            |||||||.||.|||             |.|.|...   ||  ||| ||.      :|||::.:
  Fly   301 SNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGG--PSS-SYASEMVPVSSLHTMAS-- 360

Human   413 EQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHA-----VGPSTSLPAGHSDIHSLL 472
                             |.:..|||   :|||||::|||||.     .|.:.|| |...:|.:|.
  Fly   361 -----------------VFQGVRME---ERLDDALNVLRNHCEPEMLAGVNQSL-ASIDNIDALT 404

Human   473 -----GPSHNAPIGSLNSNYGGSSLVASSRSASMV------------GTHREDSVSLNGNHSVLS 520
                 .|||   :||    .|.|..|:::.:|::|            ||..:   |:.|..|:.|
  Fly   405 SFVPNSPSH---LGS----GGNSGSVSNTSNAALVHEVLALGAAAAAGTSGQ---SVGGAGSLAS 459

Human   521 STVTTS-STDLNHKTQENYRGGLQSQS--GTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQ 582
            ..:..| ||.|..:|::.......|.|  ..|.||...|.....|.   :|.||      .|||.
  Fly   460 LKLDRSASTSLPKQTKKRKEHTAISNSVPAGVSTTSSLTSLDISDT---KPTSS------IESSN 515

Human   583 KDIKVSSRGR--------TSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRM 639
            ..::..|:|:        .||.:||:|..|..|..||||||.|||||||:|:||||||.||||||
  Fly   516 SGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIREKERRQANNARERIRIRDINEALKELGRM 580

Human   640 CQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVS---AVSAE----- 696
            |..||||:||||||.||:.||.||::||||||||||||||||||||||||..   .:||:
  Fly   581 CMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACLKRREEEKAEDGPKLSAQHHMIP 645

Human   697 PPTTLPGTHPGLSETTNP 714
            .|..:.|| ||.|..:.|
  Fly   646 QPQQVGGT-PGSSYHSQP 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TCF12	XP_011520261.1	CytochromB561_N	287..>460	CDD:286826	64/201 (32%)
TCF12	XP_011520261.1	HLH	619..672	CDD:197674	40/52 (77%)
da	NP_001356956.1	HLH	560..613	CDD:197674	40/52 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149768
Domainoid	1	1.000	86	1.000	Domainoid score	I8084
eggNOG	1	0.900	-	-		E1_KOG3910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3669
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D260626at33208
OrthoFinder	1	1.000	-	-		FOG0001459
OrthoInspector	1	1.000	-	-		otm40698
orthoMCL	1	0.900	-	-		OOG6_105744
Panther	1	1.100	-	-	LDO	PTHR11793
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4532
SonicParanoid	1	1.000	-	-		X1175
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.880