DRSC/TRiP Functional Genomics Resources

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Protein Alignment TCF7L2 and Sox15

DIOPT Version :9

Sequence 1:NP_001354872.1 Gene:TCF7L2 / 6934 HGNCID:11641 Length:619 Species:Homo sapiens
Sequence 2:NP_523739.2 Gene:Sox15 / 36575 FlyBaseID:FBgn0005613 Length:784 Species:Drosophila melanogaster


Alignment Length:600 Identity:131/600 - (21%)
Similarity:209/600 - (34%) Gaps:193/600 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   145 HQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTP--LITYS 207
            |.:...|...|:|.:               :|:|..:|...:     .:|.|...||.  |:..|
  Fly    11 HHLLTNYNSKKYPHV---------------SRTPEYSHSTGS-----DYPEHGGYLTDGRLMHES 55

Human   208 N------------EHFTPGNPPP----------HLPADVDPKTGIPRPPHPPDISPYYPLSPGTV 250
            |            ||.:|....|          ||...|.........|.|...|.|  :..||.
  Fly    56 NSDAGIYHVRQGSEHSSPSLHSPAIQSSGYENEHLNEAVLAAHSHSHSPMPMVSSAY--VGGGTA 118

Human   251 GQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIV 315
            .      |.|:...    .|:..||          .|:.:::|..|             ||..:|
  Fly   119 S------GSLINSN----IPLLGGG----------GNSVLNKFLSH-------------PHAGMV 150

Human   316 ---TPTVKQESSQSDV-----------GSL----------HSSKHQDSK------KEEEKKKPHI 350
               |..::..:|.|.:           |.|          |.....|.|      :.:..|:..|
  Fly   151 GGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRI 215

Human   351 KKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYP 415
            ::|:||||::.|..|.|:..|.....:|.::::||::|.:|:.:::..|.|.|.:.|.:||..:|
  Fly   216 RRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHP 280

Human   416 GWSARDNYGKKKKRKRDKQPG--ETNEHSE------CFLNPCLSLPPITDLSA-------PKKCR 465
            .:..|.. .:|:.:.|..|||  |.:|.|.      ...||.|:.||:...|:       ...|.
  Fly   281 NYKYRPR-RRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCN 344

Human   466 ARFGLDQQNNWCGPCRRKKKCVR--YIQGEGSCLS---------------PPS-----------S 502
            :   .:|.:....|....::.::  |......|.|               ||:           .
  Fly   345 S---TNQNHGQSTPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGY 406

Human   503 DGSLLDSPPPSPNLLGSPPRDAKSQTEQ----------TQPLSLSLKPDPLAHLSMMPPPPALLL 557
            |.|||......|    ||.|.|||:.|:          :|....|.:....|...:.|...|::.
  Fly   407 DNSLLLKKLTKP----SPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVA 467

Human   558 AEATHKASALCPN-GALD---------LPPAALQPAAPSSSIAQPSTSSLHSH--------SSLA 604
            |...:   ..|.| |.||         .||.::.....|:|: :.|.|:|..|        ||..
  Fly   468 ARGMY---VTCNNRGLLDHGHSVKGTFYPPVSVSEDDNSTSM-RNSISALQQHCNVVTSTPSSSG 528

Human   605 GTQP-QPLSLVTKSL 618
            ||.| ..:|..|.|:
  Fly   529 GTMPTSEMSSYTVSM 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TCF7L2NP_001354872.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
CTNNB1-binding. /evidence=ECO:0000250 1..53
CTNNB1_binding 17..259 CDD:400583 27/137 (20%)
Mediates interaction with MAD2L2. /evidence=ECO:0000269|PubMed:19443654 201..395 52/247 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..350 8/58 (14%)
SOX-TCF_HMG-box 353..420 CDD:238684 21/66 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..441 7/22 (32%)
Nuclear localization signal. /evidence=ECO:0000255 425..430 1/4 (25%)
Promoter-specific activation domain 459..505 10/80 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..547 19/86 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..619 17/62 (27%)
Sox15NP_523739.2 SOX-TCF_HMG-box 214..285 CDD:238684 22/70 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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