Protein Alignment TBX3 and tbx3

DIOPT Version :10

• Sequence 1: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_001027524.1
• Gene: tbx3 / 613116
• XenbaseID: XB-GENE-1018231
• Length: 701
• Species: Xenopus tropicalis
• Alignment Length: 752
• Identity: 554/752 - (73%)
• Similarity: 611/752 - (81%)
• Gaps: 61/752 - (8%)

Human     1 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIM 65
            |:|.||||||.|::|||||||.||||||||||||||||||||||.||||| ||||||||||||||
 Frog     1 MNLPMRDPVISGSAMAYHPFLSHRAPDFAMSAVLGHQPPFFPALALPPNG-AALSLPGALAKPIM 64

Human    66 DQLVGAAETGIPFSSLGPQ--AHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKS 128
            |||||||||||||||||.|  ||||||||:|||||||||||||||.|:||:||||||||||||||
 Frog    65 DQLVGAAETGIPFSSLGHQAAAHLRPLKTLEPEEEVEDDPKVHLEGKDLWEQFHKRGTEMVITKS 129

Human   129 GRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 193
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
 Frog   130 GRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPAT 194

Human   194 GEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRAN 258
            ||||||||||||||||||||||||||                    |||||||||||||||||||
 Frog   195 GEQWMSKVVTFHKLKLTNNISDKHGF--------------------TILNSMHKYQPRFHIVRAN 239

Human   259 DILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMR 323
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||.|||||
 Frog   240 DILKLPYSTFRTYVFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLALQSMR 304

Human   324 VFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPE 388
            .:|:..||:||:||||||||.|:.||||.|||.|..||||:||.:.||:||||  .||::|.||:
 Frog   305 PYDDHQKKDNGSSDESSSEQTAYKCFAQTSSPTAPAVGTSSLKGVPPSDGESD--EESRDEGGPD 367

Human   389 ACDAAKISTTTSEEPCRDKGSPAVKAHLFAAERPRD-SGRLDKASPDSRHSPATISSSTRG--LG 450
            ..::.||||||||: ||:..||....|.....|.|: |.|..|:||||||||..||||:.|  |.
 Frog   368 TGESTKISTTTSED-CRELASPPRAPHSDLGSRSREQSSRTGKSSPDSRHSPGHISSSSSGRILS 431

Human   451 AEERRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFN- 514
            .||.:||.|:.   .|.||::.  .||||.|||||||::|..|:||.|..|||.|||.||||||
 Frog   432 IEELKSPARDS---HKAEESQR--SKEAFPPLTVQTDSSAHLLSQGHLQNLGFPPGLTGQQFFNP 491

Human   515 ---GHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAA 576
               .|||..|||.|||||||||| ||||.||||:|||||:||:.:|||.|||  ::|||:|:||
 Frog   492 LGASHPLLFHPSHFAMGGAFSSM-AAGMNPLLASVSGASSGVNSIDSTVMAS--SSQGLAGSSA- 552

Human   577 TLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYS 641
             |||||||.|||||||||||||.||.|||||||||||||||     ||||||  ||.:|||||||
 Frog   553 -LPFHLQQQVLASQGLAMSPFGGLFSYPYTYMAAAAAASSA-----VHRHPF--LNAVRPRLRYS 609

Human   642 PYSIPVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSL 706
            |||.|:|..:|||||||||.|       |||| |:|.:|||:.|:|  :||:||:.||||.|:||
 Frog   610 PYSFPMPFAEGSSLLTTALHS-------LDGK-ASLLSSPAATALD--TELSSRTPTLSSGSVSL 664

Human   707 SPKLCAEKEAATSELQSIQRLVSGLEAKPDRSRSASP 743
            |||||.||| |:||||:||||||||::|.:||||.||
 Frog   665 SPKLCPEKE-ASSELQNIQRLVSGLDSKQERSRSGSP 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX3	NP_057653.3	T-box_TBX2_3-like	104..305	CDD:410314	175/200 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		32/40 (80%)
		TBX	323..403	CDD:432659	48/79 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..465		54/109 (50%)
		Transcription repression	544..695		100/150 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707		10/18 (56%)
tbx3	NP_001027524.1	T-box_TBX2_3-like	105..286	CDD:410314	175/200 (88%)
		TBX	304..381	CDD:432659	47/78 (60%)