Protein Alignment TBX3 and tbx3a

DIOPT Version :10

• Sequence 1: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_001095140.2
• Gene: tbx3a / 556870
• ZFINID: ZDB-GENE-070209-80
• Length: 689
• Species: Danio rerio
• Alignment Length: 744
• Identity: 520/744 - (69%)
• Similarity: 580/744 - (77%)
• Gaps: 60/744 - (8%)

Human     5 MRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLV 69
            ||||||.|:|||||||||||.|:|||||:|||||||||||.|||||  :|||||||.||||:||:
Zfish     1 MRDPVIQGSSMAYHPFLPHRGPEFAMSAMLGHQPPFFPALALPPNG--SLSLPGALGKPIMEQLM 63

Human    70 GAAETGIPFSSLGPQ-AHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMF 133
            ||||||:.|||||.| ||||||||:||||||||||||||||||||:.||||||||||||||||||
Zfish    64 GAAETGLHFSSLGHQAAHLRPLKTLEPEEEVEDDPKVHLEAKELWELFHKRGTEMVITKSGRRMF 128

Human   134 PPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWM 198
            |||||||:||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Zfish   129 PPFKVRCTGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWM 193

Human   199 SKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKL 263
            ||||.||||||||||||||||                    ||||||||||||||||||||||||
Zfish   194 SKVVNFHKLKLTNNISDKHGF--------------------TILNSMHKYQPRFHIVRANDILKL 238

Human   264 PYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDER 328
            ||||||||:||||:||||||||||||||||||:|||||||||||||||||||||.|||||.::|:
Zfish   239 PYSTFRTYVFPETDFIAVTAYQNDKITQLKIDHNPFAKGFRDTGNGRREKRKQLALQSMRSYEEQ 303

Human   329 HKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAA 393
            .||||||||:||.|||:|.||.||||||.||.|.::|||.|.|:.:||  .|.|:.:..|..|::
Zfish   304 QKKENGTSDDSSGEQASFKCFRQASSPAVSTAGHNHLKDFCDSDEDSD--EEDKDANAKEGPDSS 366

Human   394 KISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPV 458
            ||||||.:...:|.|   :...:|.........|.:|...||| ||.|:.|||...| ||.:|||
Zfish   367 KISTTTEDSKDQDAG---LGKSVFGESDSSSGRRSEKTRADSR-SPITLISSTTRSG-EELKSPV 426

Human   459 REGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFN----GHPLF 519
            ||   |||..:......||.:.||||||| .||||.|..|...||.||||||||||    .||..
Zfish   427 RE---PAKTTDDCRTVSKENYMPLTVQTD-GAAHLNQNHLHNFGFPPGLAGQQFFNHLGGAHPFL 487

Human   520 LHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQ 584
            ||||||.||||||:| ||||||:||.||  |.||..||.:::.|  .:|.|:|   |.:||||||
Zfish   488 LHPSQFNMGGAFSNM-AAGMGPILAAVS--SGGVGSLDGSSLPS--PSQSLTG---APMPFHLQQ 544

Human   585 HVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPV 649
            ||||||||||||||.||||||||||||||||| |||||||||||  |:.:||||||||||:| .|
Zfish   545 HVLASQGLAMSPFGGLFPYPYTYMAAAAAASS-AASSSVHRHPF--LSAVRPRLRYSPYSLP-SV 605

Human   650 PDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEK 714
            || |:|||||:..||::.  |:.|...:..||||.|:|  ||:.||    ||.|:|||||.|.||
Zfish   606 PD-STLLTTAMQPMASSG--LEVKGDGMNTSPASAALD--SEVTSR----SSGSVSLSPKTCTEK 661

Human   715 EAATSELQSIQRLVSGLEAKPDRSRSASP 743
            : ::||||||||||||||.||||:||.||
Zfish   662 D-SSSELQSIQRLVSGLEPKPDRARSVSP 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX3	NP_057653.3	T-box_TBX2_3-like	104..305	CDD:410314	172/200 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		33/40 (83%)
		TBX	323..403	CDD:432659	44/79 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..465		42/106 (40%)
		Transcription repression	544..695		94/150 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707		8/18 (44%)
tbx3a	NP_001095140.2	T-box_TBX2_3-like	99..280	CDD:410314	172/200 (86%)
		TBX	298..379	CDD:432659	44/82 (54%)