Protein Alignment TBX3 and byn

DIOPT Version :10

• Sequence 1: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_524031.2
• Gene: byn / 39349
• FlyBaseID: FBgn0011723
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 720
• Identity: 190/720 - (26%)
• Similarity: 281/720 - (39%)
• Gaps: 191/720 - (26%)

Human    50 GAAALSLPGA-LAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELW 113
            |.||:|..|| ::.....::||.|  |.|                   .|::.:.::.|:.:|||
  Fly    54 GVAAVSGGGASVSGNGGHRVVGGA--GSP-------------------NELDRNLRISLDDRELW 97

Human   114 DQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADP 178
            .:|.....||::||:||||||..|:..||||..|.|.:|::.:..|..|:|:.|..|:..|||:.
  Fly    98 LRFQNLTNEMIVTKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEV 162

Human   179 EMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILN 243
            .....:|:||:||..|..||.:.::|.|:||||..:                 ||    .|.:||
  Fly   163 PPSNPIYVHPESPNFGAHWMKEPISFAKVKLTNKTN-----------------GN----GQIMLN 206

Human   244 SMHKYQPRFHIVRANDILKLPYSTFR---TYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 305
            |:|||:||.|:||..       |..|   ||.||||:|||||||||:::|.|||..|||||.|.|
  Fly   207 SLHKYEPRVHLVRVG-------SEQRHVVTYPFPETQFIAVTAYQNEEVTSLKIKYNPFAKAFLD 264

Human   306 TGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCP 370
            .      |.:..||..       |....|......:...| ...|.|:.|..|...:..|...||
  Fly   265 A------KERPDTLYP-------HDTHYGWLIPPPTHYTA-AAAAVAAPPPLSIAQSHGLVASCP 315

Human   371 SEGESDAEAESKEEHGPE---ACDA-AKISTTTSEEPCRDKGSPAVKAHLFAAERPR------DS 425
            |       ..|.|..||.   :||. .:..::.|..|.|.  :|        ..|||      .:
  Fly   316 S-------VSSAESVGPSSGGSCDRYGRSLSSRSVAPTRT--TP--------YSRPRVVSGSGSN 363

Human   426 GRLDKAS------------PDSRHSPAT-------ISSSTRGLGAEERRSPVREGTAPAKVEEAR 471
            |....||            |.|.||.:|       .|||..|:|:...........|.:......
  Fly   364 GSAGNASSTSPQPPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVD 428

Human   472 ALPGKEAFA-PLTVQTDA---------------------AAAHLAQGPLPGLGFAPGLAGQQFFN 514
            |.|....|: |.:.|::.                     .::|  ..|.|..|..........:.
  Fly   429 ASPTASVFSYPSSWQSNGNYWNATSVPGPMPMNVCSGRNISSH--NSPSPTNGSPSYTTSSPSYT 491

Human   515 GHPLFLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLP 579
            .|.|..|..|:.|  |.:.:...|:|      .|...|.:|....|..:||
  Fly   492 IHHLTPHSHQYNM--AQTDIYGTGVG------VGGGAGTTGSPQAAYGAAA-------------- 534

Human   580 FHLQQHVLASQGLAMSPFGSLF-------PYPYTYMAAAAAASSAA-------ASSSVHRHPFLN 630
             |...|...:     ||...|:       |...:|.|:.....|.|       |:::.::..::.
  Fly   535 -HQVYHPTPT-----SPTHQLYTNAVLNAPSALSYSASGWHNGSGAEYGLYQNAAAAYYQPEYIP 593

Human   631 LNTMRPRLRYSPYSI-PVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNS 694
            |     .:.|:.:.: ||.|.      .|.....||...|.|.:.:.:....||.::.|..::..
  Fly   594 L-----EIGYATHPLEPVDVS------KTLDDPQAAMYKPSDEQGSVITLECASSSLKSSHDIKI 647

Human   695 RSSTL 699
            .||:|
  Fly   648 ESSSL 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX3	NP_057653.3	T-box_TBX2_3-like	104..305	CDD:410314	86/203 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		8/40 (20%)
		TBX	323..403	CDD:432659	18/83 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..465		32/135 (24%)
		Transcription repression	544..695		30/165 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707		4/12 (33%)
byn	NP_524031.2	T-box_TBXT_TBX19-like	87..264	CDD:410318	86/204 (42%)