DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX3 and Doc2

DIOPT Version :9

Sequence 1:	NP_057653.3	Gene:	TBX3 / 6926	HGNCID:	11602	Length:	743	Species:	Homo sapiens
Sequence 2:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	156/501 - (31%)
Similarity:	227/501 - (45%)	Gaps:	113/501 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    17 YHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSL 81
            |...:..|.||           ||.|.|.:|        :|..:..|....|.|...|
  Fly    21 YRQQIMQRIPD-----------PFPPMLPIP--------MPRHVIMPPRVTLPGVEMT------- 59

Human    82 GPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKK 146
                                     |:..:||.|||:.||||:||||||||||..::..|||:.:
  Fly    60 -------------------------LQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDE 99

Human   147 AKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTN 211
            :.|.:|::::...||||||..|:|:.||.|:|:.|:|||:||||||||..|.::.:.|:|:||||
  Fly   100 SNYCVLLEMVPIGDCRYKFSGSQWVPAGGAEPQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTN 164

Human   212 NISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPET 276
            |..|..|                    ..:|.||||||||.|::|..|:.::|::..:.::|.||
  Fly   165 NTLDNSG--------------------HIVLASMHKYQPRLHVIRTADLAQIPWAPQQAFVFAET 209

Human   277 EFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSS 341
            ||:||||||||:||:|||||||||||||:||..|. |||.              ..:.|.::...
  Fly   210 EFVAVTAYQNDRITKLKIDNNPFAKGFRETGQSRC-KRKM--------------SSSPTGEDQDQ 259

Human   342 EQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRD 406
            ..:..:..:|:.|..:.|.|.........|.|:||.....:......||   .:|::..::....
  Fly   260 SPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIKRLRSNGSAC---SLSSSLDDQSVPG 321

Human   407 KGSPAVKA---HLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVE 468
            ..|.|:.:   ||.:...|........:|...:|....:.|..|                |:.|:
  Fly   322 ASSLALGSPPPHLHSHSHPHPLQARSASSVFMQHFQQNMQSLLR----------------PSLVD 370

Human   469 EARALPGKE-----AFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAG 509
            .|....|:.     |.....:...||......||.|||...||::|
  Fly   371 LACTYFGRPHEYGGAIQASPMYPPAAMLQAGLGPHPGLNLPPGVSG 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX3	NP_057653.3	TBOX	104..307	CDD:238106	100/202 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..342		11/40 (28%)
		TBX	323..411	CDD:204975	13/87 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..465		18/110 (16%)
		Transcription repression	544..695
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..707
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	104/238 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810