Protein Alignment TBX3 and Tbx3

DIOPT Version :10

• Sequence 1: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_853669.1
• Gene: Tbx3 / 353305
• RGDID: 735203
• Length: 743
• Species: Rattus norvegicus
• Alignment Length: 745
• Identity: 701/745 - (94%)
• Similarity: 713/745 - (95%)
• Gaps: 4/745 - (0%)

Human     1 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIM 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIM 65

Human    66 DQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGR 130
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
  Rat    66 DQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSGR 130

Human   131 RMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 RMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGE 195

Human   196 QWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDI 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 QWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDI 260

Human   261 LKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 LKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVF 325

Human   326 DERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEAC 390
            |||||||.|||||||||||||||||||||||.|||||||||||||||.|||||||||||||||||
  Rat   326 DERHKKETGTSDESSSEQAAFNCFAQASSPAVSTVGTSNLKDLCPSEAESDAEAESKEEHGPEAC 390

Human   391 DAAKISTTTSEEPCRDKGSPAVKAHLFAAE--RPRDSGRLDKASPDSRHSPATISSSTRGLGAEE 453
            |.|||||||:|||.|||||||.:|.||.||  |.||:.|||||||||||||||||||||..||:|
  Rat   391 DTAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADE 455

Human   454 RRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPL 518
            .|||.|||...|||:||||||.|:|||||:|||| |.|||.||||||||||||||||||||||||
  Rat   456 HRSPGREGPVSAKVDEARALPAKDAFAPLSVQTD-ATAHLTQGPLPGLGFAPGLAGQQFFNGHPL 519

Human   519 FLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQ 583
            ||||.||||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   520 FLHPGQFAMGGAFSSM-AAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQ 583

Human   584 QHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVP 648
            |||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   584 QHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVP 648

Human   649 VPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAE 713
            |||.||||.|||||||:||||||||.|.|||||||||||||||||||||||||.|:|||||||:|
  Rat   649 VPDSSSLLATALPSMASAAGPLDGKSAVLAASPASVAVDSGSELNSRSSTLSSGSVSLSPKLCSE 713

Human   714 KEAATSELQSIQRLVSGLEAKPDRSRSASP 743
            |||||||||||||||||||||||||.|.||
  Rat   714 KEAATSELQSIQRLVSGLEAKPDRSCSGSP 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX3	NP_057653.3	T-box_TBX2_3-like	104..305	CDD:410314	200/200 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		39/40 (98%)
		TBX	323..403	CDD:432659	74/79 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..465		88/108 (81%)
		Transcription repression	544..695		144/150 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707		16/18 (89%)
Tbx3	NP_853669.1	T-box_TBX2_3-like	101..305	CDD:410314	203/203 (100%)
		TBX	323..404	CDD:432659	75/80 (94%)
		DUF5585	336..>686	CDD:465521	314/351 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..467		75/95 (79%)