Protein Alignment TBX3 and Tbx3

DIOPT Version :10

• Sequence 1: NP_057653.3
• Gene: TBX3 / 6926
• HGNCID: 11602
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_035665.2
• Gene: Tbx3 / 21386
• MGIID: 98495
• Length: 741
• Species: Mus musculus
• Alignment Length: 745
• Identity: 698/745 - (93%)
• Similarity: 714/745 - (95%)
• Gaps: 6/745 - (0%)

Human     1 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIM 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIM 65

Human    66 DQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGR 130
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse    66 DQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSGR 130

Human   131 RMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 RMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGE 195

Human   196 QWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDI 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 QWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDI 260

Human   261 LKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 LKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVF 325

Human   326 DERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEAC 390
            :||||||  ||||||||||||||||||||||.|.|||||||||||||.|||||||||||||||||
Mouse   326 EERHKKE--TSDESSSEQAAFNCFAQASSPAVSIVGTSNLKDLCPSEAESDAEAESKEEHGPEAC 388

Human   391 DAAKISTTTSEEPCRDKGSPAVKAHLFAAE--RPRDSGRLDKASPDSRHSPATISSSTRGLGAEE 453
            |||||||||:|||.|||||||.:|.||.||  |.||:.|||||||||||||||||||||..||:|
Mouse   389 DAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADE 453

Human   454 RRSPVREGTAPAKVEEARALPGKEAFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPL 518
            ||||.|||....||:||||:|.|:|||||:|||| |.||||||||||||||||||||||||||||
Mouse   454 RRSPGREGPVATKVDEARAIPAKDAFAPLSVQTD-ATAHLAQGPLPGLGFAPGLAGQQFFNGHPL 517

Human   519 FLHPSQFAMGGAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQ 583
            ||||.||||||||||| |||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   518 FLHPGQFAMGGAFSSM-AAGMGPLLATVSGASTGVSGLESTAMASAAAAQGLSGASAATLPFHLQ 581

Human   584 QHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVP 648
            ||||||||||||||||||||||||||||||||:||||||||||||||||:|||||||||||||||
Mouse   582 QHVLASQGLAMSPFGSLFPYPYTYMAAAAAASTAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVP 646

Human   649 VPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAE 713
            |||.||||.|||||||:||||||||.|||||||||||||||||||||||||||.|:|||||||:|
Mouse   647 VPDSSSLLATALPSMASAAGPLDGKAAALAASPASVAVDSGSELNSRSSTLSSGSVSLSPKLCSE 711

Human   714 KEAATSELQSIQRLVSGLEAKPDRSRSASP 743
            |||||||||||||||||||||||||.|.||
Mouse   712 KEAATSELQSIQRLVSGLEAKPDRSCSGSP 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX3	NP_057653.3	T-box_TBX2_3-like	104..305	CDD:410314	200/200 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..342		37/40 (93%)
		TBX	323..403	CDD:432659	72/79 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..465		89/108 (82%)
		Transcription repression	544..695		143/150 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..707		16/18 (89%)
Tbx3	NP_035665.2	T-box_TBX2_3-like	101..305	CDD:410314	203/203 (100%)
		TBX	323..402	CDD:432659	73/80 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	369..469		79/99 (80%)