DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBX3 and tbx-2

DIOPT Version :10

Sequence 1:NP_057653.3 Gene:TBX3 / 6926 HGNCID:11602 Length:743 Species:Homo sapiens
Sequence 2:NP_001370674.1 Gene:tbx-2 / 175698 WormBaseID:WBGene00006543 Length:423 Species:Caenorhabditis elegans


Alignment Length:406 Identity:188/406 - (46%)
Similarity:236/406 - (58%) Gaps:92/406 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    15 MAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFS 79
            ||::||            .||.     |.|.||..| |.:..|||          |.....:.||
 Worm     1 MAFNPF------------ALGR-----PDLLLPFMG-AGVGGPGA----------GGPPPNLFFS 37

Human    80 SLGPQAHLRPLKTMEPEEE--VEDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSG 142
            .|  ||...|.....|.|:  |.|||||.|:.:|||.||.:.||||||||||||:||.::|:.||
 Worm    38 ML--QAGFPPGPVGSPPEDDGVTDDPKVELDERELWQQFSQCGTEMVITKSGRRIFPAYRVKISG 100

Human   143 LDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKL 207
            ||||::|.::||::.||:.||||:|||||:||||||||||.:|||||||:|||.||||...||||
 Worm   101 LDKKSQYFVMMDLVPADEHRYKFNNSRWMIAGKADPEMPKTLYIHPDSPSTGEHWMSKGANFHKL 165

Human   208 KLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYL 272
            |||||||||||:                    ||||||||||||.|:||..|...|.||||||::
 Worm   166 KLTNNISDKHGY--------------------TILNSMHKYQPRLHVVRCADRHNLMYSTFRTFV 210

Human   273 FPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSD 337
            |.||||||||||||:|:|:|||:||||||||||.|.|:|||::||           |:. ||.:.
 Worm   211 FRETEFIAVTAYQNEKVTELKIENNPFAKGFRDAGAGKREKKRQL-----------HRM-NGDAT 263

Human   338 ESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACD---AAKISTTT 399
            :|...:.       ||.|..|.         .|||..|:.:..:.::..||...   .:.:||:|
 Worm   264 QSPPGKT-------ASLPTHSP---------HPSESNSEDDEPTLKKCKPEPSQTPTTSSLSTST 312

Human   400 SEEPCRDKGSPAVKAH 415
                     :|.:.||
 Worm   313 ---------TPTLSAH 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBX3NP_057653.3 T-box_TBX2_3-like 104..305 CDD:410314 131/200 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..342 16/40 (40%)
TBX 323..403 CDD:432659 17/82 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..465 13/61 (21%)
Transcription repression 544..695
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..707
tbx-2NP_001370674.1 T-box_TBX2_3-like 59..243 CDD:410314 134/203 (66%)
Blue background indicates that the domain is not in the aligned region.

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