Protein Alignment TCF4 and Tcf4

DIOPT Version :10

• Sequence 1: NP_001230155.2
• Gene: TCF4 / 6925
• HGNCID: 11634
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_038713.1
• Gene: Tcf4 / 21413
• MGIID: 98506
• Length: 670
• Species: Mus musculus
• Alignment Length: 671
• Identity: 658/671 - (98%)
• Similarity: 663/671 - (98%)
• Gaps: 1/671 - (0%)

Human   103 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHP 167
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Mouse     1 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGTGGHP 65

Human   168 SPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGD 232
            |||||||||||||||||||||||||||||||||||||||||||||||||| |:||||||||||||
Mouse    66 SPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRE-NVQGCHQQSLLGGD 129

Human   233 MDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYN 297
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse   130 MDMGNPGTLSPTKPGSQYYQYSSNNARRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYN 194

Human   298 RDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPH 362
            ||||||||||||.||||||||||||||||||||||||||||||.|||||||||||||||||||||
Mouse   195 RDSPGYPSSKPAASTFPSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSSHIPQSSSYCSLHPH 259

Human   363 ERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALG 427
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
Mouse   260 ERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALG 324

Human   428 KALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRL 492
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   325 KALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRL 389

Human   493 ERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHR 557
            ||||||||||||||||||||:||||||||||:|||||||||.|||||||.||||||||||||.||
Mouse   390 ERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIMGPSHNGAMGSLGSGYGTSLLSANRHSLMVGAHR 454

Human   558 EDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGD 622
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   455 EDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGD 519

Human   623 ENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDIN 687
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   520 ENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDIN 584

Human   688 EAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPP 752
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   585 EAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPP 649

Human   753 PLSLAGPHPGMGDASNHMGQM 773
            ||||||||||||||:||||||
Mouse   650 PLSLAGPHPGMGDAANHMGQM 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TCF4	NP_001230155.2	bHLH_E-protein_TCF4_E2-2	664..748	CDD:381515	83/83 (100%)
Tcf4	NP_038713.1	Essential for MYOD1 inhibition	1..83		80/81 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..244		214/220 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..320		56/57 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..378		42/42 (100%)
		Leucine-zipper	378..399		20/20 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..426		17/19 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..573		107/107 (100%)
		bHLH_E-protein_TCF4_E2-2	561..645	CDD:381515	83/83 (100%)
		Class A specific domain	622..645		22/22 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..670		31/32 (97%)