Protein Alignment TCF4 and tcf4

DIOPT Version :10

• Sequence 1: NP_001230155.2
• Gene: TCF4 / 6925
• HGNCID: 11634
• Length: 773
• Species: Homo sapiens
• Sequence 2: XP_031755521.1
• Gene: tcf4 / 100124777
• XenbaseID: XB-GENE-1011628
• Length: 705
• Species: Xenopus tropicalis
• Alignment Length: 709
• Identity: 597/709 - (84%)
• Similarity: 629/709 - (88%)
• Gaps: 42/709 - (5%)

Human   103 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHP 167
            |:|.|||||||||||||||||||||||||||||||||||||||||:|:||||||:||||||..||
 Frog     1 MNHHQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFSGTNVEDRSNSGSWGNSAHP 65

Human   168 SPSR--------------------NYGDGTPYDHMTSRDLG--SHDNLSPPFVNSRIQSKTERGS 210
            ||||                    :||:|..::|||||||.  |||||||||||:|||.|::|.|
 Frog    66 SPSRKLSCSVQASVHSHPPRRWLHSYGEGGHFEHMTSRDLSSHSHDNLSPPFVNTRIQGKSDRNS 130

Human   211 YSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKV 275
            ||.|||:|.:|||||||||||||:|.|.|.|||||||||||.||||||||||.|.|:||||.|||
 Frog   131 YSCYGRDSEMQGCHQQSLLGGDMEMANTGALSPTKPGSQYYPYSSNNPRRRPFHGSSMEVQAKKV 195

Human   276 RKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGY 340
            ||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.||
 Frog   196 RKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPAASTFPSSFFMQDGHHSSDPWSSSSGMNQAGY 260

Human   341 AGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGT 405
            .||||||||||||||||:||||||||||||||.||||||||||||||||||||||||||||||||
 Frog   261 GGMLGNSSHIPQSSSYCNLHPHERLSYPSHSSTDINSSLPPMSTFHRSGTNHYSTSSCTPPANGT 325

Human   406 DSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQ 470
            :|||.||||.|.||||||||||||||||||||||||||||||||||||||||||.||||||||||
 Frog   326 ESIMTNRGSAATGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSASTAVWSRNGGQ 390

Human   471 ASSSPNYEGPLHSL--QSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMG 533
            .|||||||||||:|  |||||||||||||||||||||||||||||||.|.::||:||||||||||
 Frog   391 TSSSPNYEGPLHTLTQQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGSHSELHGLIGPSHNGAMG 455

Human   534 GLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRG 598
            |:|||||||||||||||||||.||||||.|||||||:||||.|||||||||||||||..||||||
 Frog   456 GIGSGYGTGLLSANRHSLMVGAHREDGVNLRGSHSLVPNQVSVPQLPVQSATSPDLNSDQDPYRG 520

Human   599 MPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQ 663
            :|.|||.|:||.|||||||:|||||||.|:|||:||||||||||:||||    ||||||||||||
 Frog   521 IPTGLQAQAVSPGSSEIKSEDEGDENLHDSKSSDDKKLDDDKKDVKSIT----SNNDDEDLTPEQ 581

Human   664 KAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVR 728
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   582 KAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVR 646

Human   729 --------------ERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM 773
                          |||||||||||||||||||||:|.||||||||||||||:||:|||
 Frog   647 GNPTLLSILDLLVLERNLNPKAACLKRREEEKVSSDPSPLSLAGPHPGMGDAANHLGQM 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TCF4	NP_001230155.2	bHLH_E-protein_TCF4_E2-2	664..748	CDD:381515	83/97 (86%)
tcf4	XP_031755521.1	bHLH_E-protein_TCF4_E2-2	582..680	CDD:381515	83/97 (86%)