DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nphs1 and side-III

DIOPT Version :9

Sequence 1:NP_001035777.1 Gene:nphs1 / 692352 ZFINID:ZDB-GENE-051102-1 Length:1242 Species:Danio rerio
Sequence 2:NP_001036681.1 Gene:side-III / 4379844 FlyBaseID:FBgn0083949 Length:1689 Species:Drosophila melanogaster


Alignment Length:1505 Identity:273/1505 - (18%)
Similarity:454/1505 - (30%) Gaps:567/1505 - (37%)


- Green bases have known domain annotations that are detailed below.


Zfish    36 VTVRA--GATALLKCEVLRASG-----AVQWVKDGLLLRPLRS--LPGYP--------------- 76
            |.|.|  |.||.|.|::...:.     .|.|.::. ..:||.|  :.|.|               
  Fly    57 VAVEAVLGRTASLPCDIEPEAKDDRVYMVLWFRES-AGKPLYSFDVRGRPFEKALYWSDTNSFGP 120

Zfish    77 -RYSMTGDQKKGQYHLQILDVTLEDDGPYECQVGRSESSRPIVSRTVWLNVQIPSSQPYFQLESE 140
             .|.:||.|..   .|.:.::.|:|:|.|.|:|....|  |..:..:.|.|.:|..|......|.
  Fly   121 RAYFVTGQQPA---KLSVDNIQLDDEGVYRCRVDFQNS--PTRNHRINLTVIVPPHQILVYDASG 180

Zfish   141 E-------PWVEGEQYTVTCIAPDAKPPAEITIFRDGEELLESESYTMSG-------------SQ 185
            .       |.:||:...:||.....:|...:| :.:|...||:.|....|             |:
  Fly   181 RDVAGAVGPLLEGDNIVLTCEVRGGRPEPTVT-WMNGTRTLEAGSGVSMGRHVTVNRLEVAQISR 244

Zfish   186 DKLQNTH---------------------------------------------------------- 192
            ..|.||:                                                          
  Fly   245 SALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEI 309

Zfish   193 ------------------------AEVTIRARSSDDTRRLTCRAKNP-ASPRALETGMTMKVYFP 232
                                    :.:|...:..||...|.|...|| ....|:|..:.|.|.:|
  Fly   310 KWTQNNRPFKRGLLSTSQSNGRVISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIEDSLMMNVIYP 374

Zfish   233 PQAPMIMG--LENEEVKAGSFLKVVCMSYGGNPLATLHWTKNGEVL--STSWDVDFVSRRASSVL 293
            ||..:.:|  |..:::|.|..:...|..........:.|:.:|:.:  :.||.: .:|.|:   |
  Fly   375 PQVTLSLGSTLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQNVSWGI-IISTRS---L 435

Zfish   294 KMEVKPEDNHAVLQCQSIN---QVTRSPMSLTRTLTVPFEPAEVTLLGSFEAVEGEEINLSCSTS 355
            .::.....:.....|.:.|   :...:|::|..........:.:|::|:  ::| |::.:.|..:
  Fly   436 VLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITVIGA--SLE-EDVPIPCRVN 497

Zfish   356 SSNPPVHIRWWLG-----------------------FKELNRTEVTFAEGD-NGGMMTVSNLTHK 396
            |..|.:...|...                       ..::.||.|...|.. ...:.|||.|.:.
  Fly   498 SDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTVVESNETHFESYVETVSELIYT 562

Zfish   397 VSREDNGLSLQCEAFNKGTRFSSVRAAELIVYYPPQKVWLDAPPPNVF------------LHSGS 449
            ...|.:..:|.|...|...:.|.....:::....|..:......|.|.            :|:..
  Fly   563 PKGERDYGTLACYGRNAIGKQSDPCVFQVVPAAKPGALRNCTLRPYVVTSASLNSSNQTTMHANQ 627

Zfish   450 TL-----------------RLVCFSSGGNPTGQLTWLKNNKVV-------LTASKQVSSERGVSR 490
            .|                 |....|||||..|.......|.|.       .:|.:..|:.:.:::
  Fly   628 ILPTQYGRHESNYPHMEYVRERHNSSGGNNNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQ 692

Zfish   491 ELLLTLH------PSDNLATYRCDSSNKAKKVLSAQTKFRVLF-----------------PAVSV 532
            :.|..|.      ||..||.  .:...:.|::...|.:.:...                 ||.|.
  Fly   693 QQLQRLKKRTSFTPSQTLAA--IERQRQRKQLSQQQQQLQQQHHQATATKSGGDNKPDGSPAKSS 755

Zfish   533 K----------IVAKQKELRRGQTLDLDC---LAGSSNPTA--NISWS-LGPVILKGVDQAPKRA 581
            |          .:.:|::.::.|...|..   :..|....|  |:|.| ||    ||...:.:..
  Fly   756 KQRMRRASRDPQIQQQQQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLG----KGSSSSSRSR 816

Zfish   582 EFGGMSRTSKLSLTLEP-----------------------------------HHW---------R 602
            .....:..||.:...:|                                   ||:         |
  Fly   817 RSSSSNINSKSNNGKQPAKYFNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRR 881

Zfish   603 KRITCQAFSNVLSEGVNNFYSLDVLFPPEFSAEQPDEVQVIEDETATLPAKVSANPDEITCEWIF 667
            ||:   |.:::|:.......|..:..||..||             |:|.|..:| ..||      
  Fly   882 KRL---AANDILATVAAASTSASLSSPPASSA-------------ASLAATATA-AVEI------ 923

Zfish   668 QGEKLVKERDPRYTFSDWTLEIVNVSRRDGGDYIIECSNAEGSNRTKLRLDVQ---------YSP 723
                   |:|         :..|:....|.|      ||.:.|.::...||.|         ..|
  Fly   924 -------EQD---------VSAVDAPAADSG------SNNKRSRKSLTILDKQKQQQEQQQLLPP 966

Zfish   724 TV-RMKSDPVFV----NIGDTA----------------------------------------DLL 743
            .. ::.:.||..    |:.:||                                        |..
  Fly   967 NAPQISNQPVAAISGNNVKETAATSAHGAVAAGVKDKAPSSKEDSTDNDNDSDGDEDDDDDDDDG 1031

Zfish   744 CVADANPITSSMFSWKWMGEGERDELGEESED-------------------DGTGVLTIYEVTRD 789
            ...||...|:.       .|.:.||.||..:|                   ||.|.|..||...:
  Fly  1032 AEIDAETETND-------EEEDEDEGGEAHDDDADLDEDVAQLATDADYLADGPGDLQEYETVEE 1089

Zfish   790 RAG---------------------------------VYQCTADNGISPTGSVEGQLIVRFAPDLQ 821
            ..|                                 :|..:.|:.::...........  |..||
  Fly  1090 VDGQAKHVHMLSLEEQLDLESLEDNVEEEDDGEVDDMYNVSDDDFVASVALSTSDTTA--ATPLQ 1152

Zfish   822 K---GPQWRKVASRGDGSNDANVVCQAQGVPRVQFRWAKNGFPLDLGNPRYEETTESTGTIHTSI 883
            :   ||..|:.|::.....|:....|   :|...:...:..|              |.|.:..|:
  Fly  1153 RTTEGPHIREKATQSQTQTDSATEWQ---LPHFDYSRMEYSF--------------SNGVVTQSL 1200

Zfish   884 LTVINVSAALDYAIFTCTAHN------SMGEDSLDIQLLSTNHPDPPSDLKLLRVDQTSVTLEWM 942
            |....|:.|         .|:      ::..|:.|..:.||                  :.||.|
  Fly  1201 LGGGAVTGA---------GHDGFAGGGTINFDNYDNIIYST------------------MELECM 1238

Zfish   943 PGFDGGLTQIF--------RVRYQWAGSASYMYVDVFPPTATVYTVTGLNPSTMY-------NFS 992
            ||:||||.|.|        .::.:...|::||.|.||.     ..::.|.|...|       :..
  Fly  1239 PGYDGGLQQQFFLEAYDSKTMKLRLNMSSTYMDVPVFR-----IDLSDLMPMDYYPDAHPALHLV 1298

Zfish   993 VNALNSIGESS--YADNNKILTVTTADAKEADG--GVSTADQDSALAGG----GLPVYVVVILVV 1049
            |.::|..|.|.  ..:|   :.:..|| |.:||  |:|.....:.|||.    |:.|..||::.|
  Fly  1299 VYSVNQKGRSEPIVLEN---VPINEAD-KRSDGRMGLSILPLAALLAGTLFTVGIAVLSVVVIAV 1359

Zfish  1050 GGVLFLLNPFICFLLARWKRRRSLKGNTSSISQETK--SEEQRSTASSSTRYASRELINASAQRT 1112
                               |||..:|..:....:.|  ..:...||...|....:.|:.|   .|
  Fly  1360 -------------------RRRRGQGARNMCDDKDKHLGMDVTVTAPLETGAGHQRLVVA---YT 1402

Zfish  1113 LLVDSSSEPD 1122
            |......:||
  Fly  1403 LKQGIEKQPD 1412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nphs1NP_001035777.1 IG_like 33..126 CDD:214653 29/114 (25%)
Ig 133..216 CDD:386229 24/185 (13%)
Ig 261..313 CDD:386229 9/56 (16%)
Ig 333..419 CDD:386229 20/109 (18%)
ig 439..511 CDD:365836 21/113 (19%)
IG_like 637..719 CDD:214653 15/81 (19%)
Ig_3 723..800 CDD:372822 24/173 (14%)
Ig_hNephrin_like 814..922 CDD:143250 22/116 (19%)
FN3 921..1012 CDD:238020 25/107 (23%)
side-IIINP_001036681.1 IG_like 59..166 CDD:214653 28/112 (25%)
V-set 59..166 CDD:284989 28/112 (25%)
ig 190..268 CDD:278476 15/78 (19%)
IG_like 192..259 CDD:214653 15/67 (22%)
Ig 296..361 CDD:299845 7/64 (11%)
IG_like 391..468 CDD:214653 14/80 (18%)
IGc2 392..454 CDD:197706 10/65 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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