DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp46a1.3 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_001038763.1	Gene:	cyp46a1.3 / 692332	ZFINID:	ZDB-GENE-060519-40	Length:	491	Species:	Danio rerio
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	118/512 - (23%)
Similarity:	213/512 - (41%)	Gaps:	105/512 - (20%)

- Green bases have known domain annotations that are detailed below.

Zfish    13 LLSAVFVVFLAYCLYIHQVHQKYDHIPGPP--RDNFLLGHIPTINRVTKSERHMNDLLLIWAEKY 75
            ||:::....|.|..|    ...|..:.|.|  |.:||.||...:..|     |.::||   .|.|
  Fly     7 LLTSLLSFLLGYLRY----RFTYWELRGIPQLRPHFLFGHFFRLQSV-----HYSELL---QETY 59

Zfish    76 ----GPVYRLNSFHY-----VIINVHCPEATKTIMMSP--------KYLKDPFIYKRLFGLFGKR 123
                |......::.:     |::::   :..|.:::..        .:..|| :...||.|.|:.
  Fly    60 DAFRGSAKVAGTYVFLRPMAVVLDL---DLVKAVLIRDFNNFVDRRSFHGDP-LTANLFNLQGEE 120

Zfish   124 FLGYGLVTATDHDIWYRQRRIMDPAFSSSYLRGLISTFNEMSERLMDKLEEMAINKTPAV--MHD 186
                          |...|..:.|.|:|..::.:..|.:.::::|....:|: :....||  :||
  Fly   121 --------------WRNLRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDEL-VGSQGAVLELHD 170

Zfish   187 LVNCVTLDIICKVAFGVDLNLFKQTDNPFQQAIEQCLQGMVLDLRDPFCKFFPKNWKAIQET--- 248
            |:...|.|:|...|||.:.:..::....|:|...:..:.....:|          |:..:.|
  Fly   171 LMARYTTDVIGSCAFGTECSSLREPQAEFRQVGRRIFRNSNRSIR----------WRIFKMTYLS 225

Zfish   249 ----KGATVLLRKTGEQWIQNR--KTAVEIGEDV---PNDILTQILKTAKEEKVNNTK--DHEQM 302
                .|..|.:.........||  :..||:.|..   .||.:..:|...::|   |.|  ..|||
  Fly   226 SLAKLGLPVRILHPDITKFFNRIVRETVELRERENIRRNDFMDLLLDLRRQE---NGKGLTMEQM 287

Zfish   303 LDNFVTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEVLGTKRDISYEDLGKFTYLSQVL 367
            ......||:||.||:::.:|:|:.||.::.::.::.:.|:::.:|....::||.:.:..||.|.:
  Fly   288 AAQAFVFFVAGFETSSSNMSYALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTI 352

Zfish   368 KETLRLYPTAPGTNRWLHEDMVINGIKIP---GGISVIFSSYVAQRL--------EKHFKDPLKF 421
            .||||.||......|...||     .:||   ||..|:.....:..:        .:.:.:|.:|
  Fly   353 TETLRKYPALSSLTRLASED-----YEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEF 412

Zfish   422 DPERFNVNAPKPYY--CYYPFSLGPRSCLGQVFSQATPAEGALAQLLTQLLTLCSHF 476
            .||||..:|.:..:  .:..|..|||:|:|..|.:        .|:...|:||...|
  Fly   413 RPERFAPDACRERHPTAFLGFGDGPRNCIGLRFGR--------MQVKVGLITLLRRF 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp46a1.3	NP_001038763.1	p450	39..452	CDD:278495	106/460 (23%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	111/483 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900