Protein Alignment TBXAS1 and Cyp6a22

DIOPT Version :10

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_652075.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 155/587 - (26%)
• Similarity: 257/587 - (43%)
• Gaps: 128/587 - (21%)

Human    18 VALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPF-IGNLTFFRQG--FWESQMELRKLY----G 75
            |||.:..||:..|:..:.:|...:.|: ..:|:.| :||:..||:.  |.:....:.:.:    .
  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68

Human    76 PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LFLRD-KRWEEVR 136
            |..|:::..|..:::::.::.||:|:::|:||.:|   |:......|.:   ||..| .:|..:|
  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDR---GMYHNERDDPLTGHLFRIDGPKWRPLR 130

Human   137 GALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLI 201
            ..:...|:..|:..:...:.:.       |::..|                       .|.....
  Fly   131 QKMSPTFTSAKMKYMFPTVCEV-------GEELTQ-----------------------VCGELAD 165

Human   202 SQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFV---------- 256
            :..|.:|        |.||..      ..||:||:...|||...:..:.||..|.
  Fly   166 NAMCGIL--------EIGDLM------ARYTSDVIGRCAFGVECNGLRNPEAEFAIMGRRAFSER 216

Human   257 KHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKN-RDELNGFFNKLIRNVIALRDQQAAEER 320
            :|||....|         :.|||.:    ||.|..:. ..::..|:..::|..:..|::|...
  Fly   217 RHCKLVDGF---------IESFPEV----ARFLRMRQIHQDITDFYVGIVRETVKQREEQGIV-- 266

Human   321 RRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFL 385
            |.||:.::::.:....                                   ||::|:..|||||.
  Fly   267 RSDFMNLLIEMKQRGE-----------------------------------LTIEEMAAQAFIFF 296

Human   386 IAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFC--SLEEGLPYLDMVIAETLR 448
            .||::...:||.||.|.||..|..|.||..|:|.....|.. ||.  |::| |.|:::|||||||
  Fly   297 AAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNG-EFTYDSMQE-LRYMELVIAETLR 359

Human   449 MYPPAFRFTREAAQDCEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQH 510
            .||...:.||.:.......|.|   |..|.:|.:.|..:||||..:|.|..|.||||.|:...|.
  Fly   360 KYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQR 424

Human   511 RPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ-LESKSALGPKNGVYI 574
            ....:||||.|||:|:|:|.|.::..:.|:.:|..|.|..||.|...:: |:|...|.|.||:|:
  Fly   425 PTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYL 489

Human   575 KI 576
            |:
  Fly   490 KV 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	138/524 (26%)
Cyp6a22	NP_652075.1	CYP6-like	66..488	CDD:410679	138/520 (27%)