Protein Alignment TBXAS1 and Cyp4d8

DIOPT Version :10

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 532
• Identity: 131/532 - (24%)
• Similarity: 210/532 - (39%)
• Gaps: 132/532 - (24%)

Human    65 ESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD 129
            :.:.::..|.||:|...:|....::...|....:|..|....|.:                  ..
  Fly    23 DRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLKFGH------------------LQ 69

Human   130 KRWEEVRGALMSAFSPEKLNELGLLIMQERIKGH---------MG-------GQQAPQR---IPP 175
            :.|...|..:||  ...:||| .||..||.:..|         :|       |:...||   |.|
  Fly    70 RVWIFNRLLIMS--GDAELNE-QLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITP 131

Human   176 TRLSKPSGIYVNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVA 240
            |           .|::.|. ..|.:..|..::.:..|.:.| :|:.||:.|..|....|::|..|
  Fly   132 T-----------FHFSILE-QFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDIIAETA 183

Human   241 FGTPVDSWQAPEDPF---VKHCK-----RFFEFCIPRPILVLLLSFPSI---MVPLARILP---- 290
            .||.:.:......|:   |..|.     ||....: :..|:..|:.|.:   ...|.|.:.
  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYL-QVELLFTLTHPHLKWRQTQLIRTMQEFTI 247

Human   291 ---NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSS 352
               .|.|..|....:||:...    |:....:||...|.::|        |...|
  Fly   248 KVIEKRRQALEDQQSKLMDTA----DEDVGSKRRMALLDVLL--------MSTVD---------- 290

Human   353 TGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE- 416
                            .||||.|||..:...|:..|::..|:.|||..:.|:.:|:.|.|:|.|
  Fly   291 ----------------GRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEI 339

Human   417 VDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPA----------FRFTREAAQDCEVLGQ 469
            |.|.......|  .|:.:  .|.|::.||.|:||||||.          |::|.....|     .
  Fly   340 VQVLGTDRSRP--VSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGD-----G 397

Human   470 RIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLE 534
            .||||:.:.:.:..:|..||.:|:|:.|.|||.  |...:..||..:||.||||:|:|.:...||
  Fly   398 VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLE 460

Human   535 VKLTLLHVLHKF 546
            :|:.|..::.::
  Fly   461 MKMMLAKIVREY 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	131/524 (25%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	122/489 (25%)