Protein Alignment TBXAS1 and Cyp9c1

DIOPT Version :9

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_523850.1
• Gene: Cyp9c1 / 37941
• FlyBaseID: FBgn0015040
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 176/611 - (28%)
• Similarity: 284/611 - (46%)
• Gaps: 138/611 - (22%)

Human    15 MVTVALS--VALLALL--KWYSTSAFSRLEKLGLRHPKPSPFIGNLTFF----RQGFWESQMEL- 70
            ||.|.||  ||.:.||  || |...|....|.|:.|.||.|.:||:.:.    ::.:.:..::|
  Fly     1 MVFVELSIFVAFIGLLLYKW-SVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLH 64

Human    71 -----RKLYG------PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR---MASGLEFKSV- 120
                 .|:||      ||  |||        |:|::|:||.::||..|||.   :..|....||
  Fly    65 LRLKQHKVYGVFNLRDPL--YYL--------SDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVI 119

Human   121 ADSVLFLRDKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIY 185
            :.|:|.|||:||:::|..|...|:..|:.::
  Fly   120 SKSLLSLRDRRWKQMRSTLTPTFTSLKIRQM---------------------------------- 150

Human   186 VNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDA-FDIQRCYCNYTTDVVASVAFGTPVDSWQ 249
                :..:.||.|    :|.|.    ::|..::|.: .:::..:..||.||:|:.|||..|:|::
  Fly   151 ----FELIHFCNV----EAVDF----VQRQLDAGTSELELKDFFTRYTNDVIATAAFGIQVNSFK 203

Human   250 APEDPFVKHCKRFFEFCIPRPILVLL-LSFPSIMVPL-ARILPNKNRDELNGFFNKLIRNVIALR 312
            .|.:.|....:|..||.....:.|:| :..|.:|..| ..::...|.|    :|.||:...:..|
  Fly   204 DPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNNVD----YFKKLVFGAMKYR 264

Human   313 DQQAAEERRRDFLQMVLDARH--------SASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMA 369
            .:|:..  |.|.:.::::|:.        ||.....||.....|
  Fly   265 KEQSIV--RPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFND--------------------- 306

Human   370 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEK--HMAPEFCSL 432
                 |:::.|..:|..||:|.:...|||.:|.|..||:.|||||.|:...||:  ....::.:|
  Fly   307 -----DDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTL 366

Human   433 EEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ------RIPAGAVLEMAVGALHHDPEHW 491
             .|:.||:.|::|:||.:||||...|....|.::..:      .:....::.:.||||||||:::
  Fly   367 -MGMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHINVGALHHDPDNF 430

Human   492 PSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQV 556
            |.||.|.||||..|.:.:.|.|||||||.|.|||:|.||.|:|||..:..::  .|:...|..:.
  Fly   431 PEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLV--LRYHLKPTDRT 493

Human   557 PLQLESKSA---LGPKNGVYIKIVSR 579
            |..:.|..:   |.|:...:.|:.||
  Fly   494 PADMMSSISGFRLLPRELFWCKLESR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	157/570 (28%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	157/567 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	1	0.950	-	0	Normalized mean entropy	S4378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm41379
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850