Protein Alignment TBXAS1 and Cyp317a1

DIOPT Version :10

• Sequence 1: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 121/516 - (23%)
• Similarity: 218/516 - (42%)
• Gaps: 114/516 - (22%)

Human    75 GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD----SVLFLRDKRWEEV 135
            ||.||:|...:...:|.:.::|:|:::::|.||.:|   ||.....:|    .:..||.:.|:|:
  Fly    76 GPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDR---GLYCNQKSDPLSGDLYALRGESWKEM 137

Human   136 RGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPL 200
            |..|..:...::::.|...:.:|       .:|....:..|.:|:|   :..:|
  Fly   138 RQKLDPSLEGDRMSLLYDCLYEE-------AEQLLLTVNSTLMSQP---HSTVH----------- 181

Human   201 ISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGT--------PVDSW-QAPEDPFV 256
                                   ||:....|....:|...||.        |::.: |..|....
  Fly   182 -----------------------IQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALN 223

Human   257 KHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERR 321
            .|...:.       :.::::.||:....|......|..:|   :|.||:.:::..|  :.:.:.:
  Fly   224 SHKHGYL-------MNLMMIRFPNFCRMLRMRRTPKQAEE---YFIKLLTSIVEQR--ETSGKPQ 276

Human   322 RDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLI 386
            :|:||:::|         |:..:.:             :.|::..........:|:...|.:||.
  Fly   277 KDYLQLLID---------VKALEFI-------------THQYEADKELGAHLQNELAAHAVVFLK 319

Human   387 AGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG---LPYLDMVIAETLR 448
            ||||...||||:..|.||.:|:.|.::..||....|:|   :.....||   |.::..||.||||
  Fly   320 AGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERH---DGHITHEGIKSLSFMGQVINETLR 381

Human   449 MYPPAFRFTREAAQDCEV-------LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEA 506
            |:|......|....|..|       |.:.:    .|.:...|:||||:.:|.||.|.|:|::...
  Fly   382 MHPITPYILRRTLNDYAVPDHPKYILVKEL----FLIIPTHAIHHDPDIYPDPEEFKPDRWSGPR 442

Human   507 RQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPL-QLESKSAL 566
            .......|:..||.|.|||:|::...|:::|.|..:|.::.|..  .|:.|| .||...||
  Fly   443 DSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSL--NTRKPLINLEDGIAL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	121/516 (23%)
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	121/516 (23%)