DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBXAS1 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_001159725.2	Gene:	TBXAS1 / 6916	HGNCID:	11609	Length:	579	Species:	Homo sapiens
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	151/572 - (26%)
Similarity:	264/572 - (46%)	Gaps:	93/572 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    20 LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQG------FWESQMELRKLYGPLC 78
            ::|||||:|.:|.....:..::.|:....|....||:...::.      |.:...:.|:...|..
  Fly    10 VAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFV 74

Human    79 GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LF-LRDKRWEEVRGAL 139
            |::..:.....:.:.::.||:|:::||||:|:   |:.:....|.:   || |...:|..:|..|
  Fly    75 GFFFFQSPAAFVIDLELAKQILIKDFSNFSNK---GIFYNEKDDPISAHLFNLDGAQWRLLRNKL 136

Human   140 MSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLISQA 204
            .|.|:..|:                            :|..|:.:.|...:.|:....||
  Fly   137 SSTFTSGKM----------------------------KLMYPTVVSVANEFMTVMHEKVP----- 168

Human   205 CDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPR 269
                         .....:|:.....:|.||:.:.|||...:|.:..:..|:...||..   :.:
  Fly   169 -------------KNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSL---VDK 217

Human   270 PILVLLLSFPSIMVPLARILPN-KNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARH 333
            ....||..|......|||.|.. :....:..|:::::...:|:|:::  ..:|.||:.|:::.::
  Fly   218 RHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKE--HIKRNDFMDMLIELKN 280

Human   334 SASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSF 398
            . ..|.:::.|:||.                       ||::|::.|||:|.|||:|..::|:.|
  Fly   281 Q-KEMTLENGDVVRG-----------------------LTMEEVLAQAFVFFIAGFETSSSTMGF 321

Human   399 ATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQD 463
            |.|.||.|||.|:|:..||:...|:|.........:.|.||:.|:.||||:|.......|.||:.
  Fly   322 ALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKR 386

Human   464 CEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 525
            ..|.|..   |.||..:.:...|:||||..:|.|..|.||||:.|.........:||||.|||:|
  Fly   387 YVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNC 451

Human   526 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALGPKNGVYIKI 576
            :|:|.|.::.::.|..::..|:|..|.:|..||..:.|| .||.|:|:|:|:
  Fly   452 IGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	142/543 (26%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	142/541 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820