DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBXAS1 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_001159725.2	Gene:	TBXAS1 / 6916	HGNCID:	11609	Length:	579	Species:	Homo sapiens
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	155/589 - (26%)
Similarity:	257/589 - (43%)	Gaps:	121/589 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    16 VTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLT------FFRQGFWESQMELR-KL 73
            |.:.|.:.::..:.||....|:..::.|:.|.:|....||.:      .|...|..:..:|| |.
  Fly     3 VMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPYGNTSELMKTVHFADIFKRTYNKLRNKT 67

Human    74 YGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD-----SVLFLRDKRWE 133
            .||..|:|:..:..:|:::.|..|.||:..|..|.:|   |: |.:..|     :::.:..::|:
  Fly    68 DGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDR---GV-FHNERDDPLSANLVNIDGQKWK 128

Human   134 EVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMV 198
            .:|..|...|:..|:.                                              .|.
  Fly   129 TLRQKLTPTFTSGKMK----------------------------------------------TMF 147

Human   199 PLISQACDLLLAHLKRYAES-GDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFV------ 256
            |.|....|.|:......|.: .|:.:|......:|.||:.|.|||....|...|:..||
  Fly   148 PTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFGLDCHSLSDPKAKFVQMGTTA 212

Human   257 ----KHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAA 317
                :|.|         .:.:||...|.:   .|::.......|:..|:..:||:.:..|.:.
  Fly   213 ITERRHGK---------SMDLLLFGAPEL---AAKLRMKATVQEVEDFYMNIIRDTVDYRVKN-- 263

Human   318 EERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAF 382
            ..:|.||:.|:::.:        ..||        .|.|.|            .||.:||..|||
  Fly   264 NVKRHDFVDMLIEMK--------LKFD--------NGDKEN------------GLTFNEIAAQAF 300

Human   383 IFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLEEGLPYLDMVIAET 446
            ||.:||:|..:.|:.||.|.||.:.|.|:||..|:: |.|:.:...::.|:.| :.||:.||.||
  Fly   301 IFFLAGFETSSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMRE-MTYLEKVIDET 364

Human   447 LRMYPPAFRFTREAAQDCEVLGQR--IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ 509
            :|..|......|.|.|..:....:  |..|..:.:...|:|||||.:|.||.|.||||..:..||
  Fly   365 MRKRPVVGHLIRVATQHYQHTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQ 429

Human   510 HRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP-ETQVPLQLESKS-ALGPKNGV 572
            ....|:||||.|||:|:|:|.|.::|.:.:..::|.|:|:..| :|.|||:..:.. .|..|.|:
  Fly   430 RPACTFLPFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGI 494

Human   573 YIKI 576
            ::|:
  Fly   495 HLKV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	147/556 (26%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	148/556 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820