DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBXAS1 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_001159725.2	Gene:	TBXAS1 / 6916	HGNCID:	11609	Length:	579	Species:	Homo sapiens
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	153/581 - (26%)
Similarity:	262/581 - (45%)	Gaps:	105/581 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    16 VTVALSVALLA--LLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR-----QGFWESQMELRKL 73
            |.:|:.|.|:.  ||||  ..|....:.|.:...:|...:|:||..:     ...|.......:.
  Fly     6 VLLAIVVVLVGYLLLKW--RRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRG 68

Human    74 YGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LFLRD-KRWEE 134
            .||..|:|..:|..|::.:..:.|.:|::.|:.||:|   |....:..|.:   |||.| ::|:.
  Fly    69 TGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDR---GFYHNTEDDPLSGQLFLLDGQKWKS 130

Human   135 VRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVP 199
            :|..|...|:..|:..:...:::   .||.                                .:.
  Fly   131 MRSKLSYTFTSGKMKYMFPTVVK---VGHE--------------------------------FIE 160

Human   200 LISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPF-VKHCKRFF 263
            :..||           .|.....:::.....:||||:.:.|||....|.:.||..| |...:..|
  Fly   161 VFGQA-----------MEKSPIVEVRDILARFTTDVIGTCAFGIECSSLKDPEAEFRVMGRRAIF 214

Human   264 EFCIPR--PI-LVLLLSFPSIMVPLARILPNK-NRDELNGFFNKLIRNVIALRDQQAAEERRRDF 324
            |   .|  || :..:.||.:    |||.|..| ..:|...||.:::|..:|.|::.  ..||.||
  Fly   215 E---QRHGPIGIAFINSFQN----LARRLHMKITLEEAEHFFLRIVRETVAFREKN--NIRRNDF 270

Human   325 LQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGY 389
            :..::|.::  ||:          ..|.:|...|             ||::|:..|||:|..||:
  Fly   271 MDQLIDLKN--SPL----------TKSESGESVN-------------LTIEEMAAQAFVFFGAGF 310

Human   390 EIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAF 454
            |..:.|:.||.|.||.:.|.|:::.:|......|:.........:.:.|||.||:||||:|....
  Fly   311 ETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLP 375

Human   455 RFTREAAQDCEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYL 516
            ...||..:|.||.|..   |..|..:.:..||:|.|.:.:.:|.||||:.|:.|..::.....:|
  Fly   376 VLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWL 440

Human   517 PFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSAL-GPKNGVYIKI 576
            |||.|||:|:|:|.|.::.:..|..::::|:|..|.:|.:|:....|:.| ..:.|:::|:
  Fly   441 PFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLKV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	142/546 (26%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	142/546 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820